Dirozalkib
Dirozalkib is an orally active and blood-brain barrier-penetrant ALK tyrosine kinase inhibitor. Dirozalkib inhibits the proliferation of ALK fusion-positive and ALK TKI-resistant tumor cells, and inhibits tumor growth in PDX and intracranial xenograft lung cancer models. Dirozalkib can be used for research related to non-small cell lung cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1893419-37-8
- Formule: C27H32ClN5O4S
- Masse moléculaire:558.09
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dirozalkib (50 mg/kg; p.o.; once daily; for 21 consecutive days) produces potent tumor growth inhibition in the LU-01-0414 non-small cell lung cancer PDX model[1].
Dirozalkib (100 mg/kg; p.o.; once daily; 14 days) inhibits intracranial tumor growth and prolongs survival in the H2228-luc non-small cell lung cancer xenograft model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Patient-Derived Xenograft (PDX)
- Patient-Derived Orthotopic Xenograft (PDOX)
- Brain Orthotopic Xenograft
- Splenic/Portal-Vein Liver Metastasis Xenograft
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Cell Viability Determination by MTT Colorimetric Assay
- Intraperitoneal/Peritoneal Dissemination Xenograft
Chemical Information
-
CAS No. 1893419-37-8
-
Masse moléculaire 558.09
-
Formule C27H32ClN5O4S
-
SMILES
O=S(C1=C(NC2=NC(NC3=C4OCCOC4=C(C5CCNCC5)C(C)=C3)=NC=C2Cl)C=CC=C1)(C(C)C)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dirozalkib Related Classifications
HY-172426 Related Classifications
Powered by Bioz
Keywords
- Dirozalkib
- 1893419-37-8
- Anaplastic lymphoma kinase (ALK)
- ALK TKI-resistant tumor cells
- ALK fusion-positive tumor cells
- ALK resistance mutations
- ALK tyrosine kinase
- ATP site
- STAT3 signaling
- autophosphorylation
- blood-brain barrier penetration
- intracranial xenograft
- non-small cell lung cancer
- Inhibitor
- inhibitor
- inhibit