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Cat. No.: HY-116562

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DK-139

DK-139 is a polyphenol compound bearing a cinnamaldehyde scaffol. DK-139 inhibits clonogenic growth of Cisplatin (HY-17394)-resistant human ovarian cancer. DK-139 can be used for the research of Cisplatin-resistant ovarian cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1426059-23-5
Formule: C₁₈H₁₈O₅
Masse moléculaire:314.33

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DK-139 Chemical Structure

CAS No.: 1426059-23-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780cisR	GI₅₀	11.3 μM Compound: 17	Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay	[PMID: 24565968]

In Vitro

DK-139 (Compound 17) (5-20 μM; 7 days) inhibits clonogenic growth of Cisplatin (HY-17394)-resistant human ovarian cancer A2780/Cis cells with a GI₅₀ of 11.30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Cisplatin-resistant human ovarian cancer A2780/Cis cells
Concentration:

5, 10, 20 μM
Incubation Time:

7 days
Result:

Exhibited a half-maximal cell growth inhibitory concentration (GI₅₀) of 11.30 μM.

Chemical Information

CAS No. 1426059-23-5
Masse moléculaire 314.33
Formule C₁₈H₁₈O₅
SMILES

O=C(C1=CC(OC)=CC=C1O)/C=C/C2=CC(OC)=CC(OC)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Shin SY, et al. Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin-resistant A2780/Cis ovarian cancer cells. Bioorg Med Chem. 2014;22(6):1809-1820. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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