Doliroside A
Doliroside A is an Aβ42-binding agent with an IC50 of 26.57 μM for Aβ42. Doliroside A binds to Aβ42 nuclei and oligomers to form stable complexes, suppresses Aβ42 fibrillation, and redirects Aβ42 into off-pathway, amorphous oligomers. Doliroside A can be used for the research of alzheimer’s disease (ad).
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- CAS No.: 93078-67-2
- Formule: C37H58O11
- Masse moléculaire:678.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vitro
Doliroside A (2.5-250 μM; up to 40 h) potently inhibits Aβ42 fibrillogenesis with an IC50 of 26.57 μM, showing concentration-dependent reduction of ThT fluorescence associated with Aβ42 fibril formation[1].
Doliroside A (125 μM; up to 30 h) suppresses the increase of β-sheet content in Aβ42 and inhibits the formation of insoluble β-sheet-rich fibrils during Aβ42 aggregation[1].
Doliroside A (125 μM; 24 h) alters Aβ42 aggregation morphology, redirecting the formation of fibrillar aggregates into amorphous oligomers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 93078-67-2
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Masse moléculaire 678.85
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Formule C37H58O11
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SMILES
C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])CC(C)(CC4)C)C(O)=O)C)([H])[C@@]5([C@@]([C@@](C)([C@H]([C@H](C5)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)C(OC)=O)([H])CC1)C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Doliroside A Related Classifications
HY-N17929 Related Classifications
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