DS37571084
DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC50 value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism.
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- CAS No.: 2460353-87-9
- Formule: C28H30Cl2N4O2
- Masse moléculaire:525.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PTH1R 0.17 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| CHO-K1 | IC50 |
0.17 μM
Compound: 12; DS37571084
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Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
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[PMID: 32345459] |
Chemical Information
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CAS No. 2460353-87-9
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Masse moléculaire 525.47
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Formule C28H30Cl2N4O2
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SMILES
O=C1N(C2=CC=C(NCCNC3CCOCC3)C=C2)C4=CC(Cl)=CC=C4C5=CC(Cl)=CN=C5C1(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS37571084 Related Classifications
HY-131206 Related Classifications
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