Elocalcitol
Based on 1 Customer Validation
Elocalcitol (BXL-628), a vitamin D analogue, is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells.
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- Pureté: 99.15%
- CAS No.: 199798-84-0
- Formule: C29H43FO2
- Masse moléculaire:442.65
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Elocalcitol (BXL-628) (0.00-10 nM; 24-48 h) is able to inhibit both proliferation and invasion of DU145 cells[2].
Elocalcitol (10 nM; 8 h) inhibits KGFR autotransphosphorylation and downstream PI3K/AKT activation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DU145 cells
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Concentration:0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM
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Incubation Time:48 h
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Result:Inhibited dose dependently DU145 cell proliferation with an IC50 of 22.1 pM.
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Cell Line:DU145 cells
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Concentration:10 nM
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Incubation Time:24 h
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Result:Was able to inhibit invasion of DU145 cells.
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Cell Line:DU145 cells
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Concentration:10 nM
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Incubation Time:8 h
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Result:Suppressed KGFR autotransphosphorylation and downstream PI3K/AKT activation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult Balb/c female mice was induced by injection of syngeneic endometrial tissue fragments[1].
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Dosage:100 μg/kg
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Administration:p.o.; once a day; for 14-28 days
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Result:Was able to reduce total lesion weight up to 70% upon.
Was shown to reduce the capacity of mouse endometrial cells to adhere to collagen.
Inhibited macrophage recruitment and inflammatory cytokine secretion.
Chemical Information
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CAS No. 199798-84-0
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Appearance Solid
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Masse moléculaire 442.65
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Formule C29H43FO2
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Color White to off-white
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SMILES
C[C@@]12[C@](CC=C2[C@@H](C)C/C=C/C(CC)(O)CC)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)F)=C
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Synonyms
BXL-628; Ro-26-9228
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 30 mg/mL (67.77 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Mariani M, et al. The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation. Hum Reprod. 2012 Jul;27(7):2010-9. [Content Brief]
[2]. Marchiani S, et al. The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells. J Cancer Res Clin Oncol. 2006 Jun;132(6):408-16. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2591 mL | 11.2956 mL | 22.5912 mL | 56.4780 mL |
| 5 mM | 0.4518 mL | 2.2591 mL | 4.5182 mL | 11.2956 mL | |
| 10 mM | 0.2259 mL | 1.1296 mL | 2.2591 mL | 5.6478 mL | |
| 15 mM | 0.1506 mL | 0.7530 mL | 1.5061 mL | 3.7652 mL | |
| 20 mM | 0.1130 mL | 0.5648 mL | 1.1296 mL | 2.8239 mL | |
| 25 mM | 0.0904 mL | 0.4518 mL | 0.9036 mL | 2.2591 mL | |
| 30 mM | 0.0753 mL | 0.3765 mL | 0.7530 mL | 1.8826 mL | |
| 40 mM | 0.0565 mL | 0.2824 mL | 0.5648 mL | 1.4120 mL | |
| 50 mM | 0.0452 mL | 0.2259 mL | 0.4518 mL | 1.1296 mL | |
| 60 mM | 0.0377 mL | 0.1883 mL | 0.3765 mL | 0.9413 mL |
Elocalcitol Related Classifications
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