Ferrioxamine B
Ferrioxamine B is a bacterial desferrioxamine siderophore produced by actinomycetes. Ferrioxamine B acts as a ligand for FpvB and FoxA, and is transported into Pseudomonas aeruginosa via the FpvB and FoxA transporters. Ferrioxamine B competitively binds to FpvB, thereby antagonizing the uptake of thiostrepton into Pseudomonas aeruginosa. Ferrioxamine B can provide an iron source to support the growth of Pseudomonas aeruginosa under iron-limiting conditions.
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- CAS No.: 14836-73-8
- Formule: C25H45FeN6O8
- Masse moléculaire:613.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Ferrioxamine B-Fe3+ (1 hour) binds FpvB in P. aeruginosa PA14 ΔfpvA ΔfpvB mutant with two distinct sites (Kd1 = 100 ng/mL, Kd2 = 270,000 ng/mL) and is taken up via a proton motive force-dependent mechanism[1].
Ferrioxamine B (0.0-10 μg/mL) competes with thiostrepton (0.0-17 μg/mL) for binding to FpvB in P. aeruginosa PA14 ΔfpvA ΔfpvB mutant, reducing Thiostrepton (HY-B0990) susceptibility[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14836-73-8
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Masse moléculaire 613.51
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Formule C25H45FeN6O8
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SMILES
NCCCCCN1[O-][Fe+3]23([O]=C1CCC4=O)([O-]N(CCCCCN5)C(C)=[O]3)[O-]N(CCCCCN4)C(CCC5=O)=[O]2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ferrioxamine B Related Classifications
HY-185180 Related Classifications
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