FK-3000
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and HIV-1.
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- CAS No.: 1054312-81-0
- Formule: C22H27NO7
- Masse moléculaire:417.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
FK-3000 (0-5 μg/mL; 48 h) inhibits cell proliferation, with IC50s of 0.52, 0.77, 0.22, 2.70, 0.40, and 1.90 μg/mL for MDA-MB-231, MCF-7, PC-3, A-431, HT-29, and CT-26 cells, respectively[1].
FK-3000 (0.5-5.0 μg/mL; 24-48 h) induces MDA-MB-231 cell apoptosis in a dose- and time-dependent manner[1].
FK-3000 (0.5-5.0 μg/mL; 24-48 h) induces G2/M phase arrest in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner[2].
FK-3000 (0.5-5.0 μg/mL; 60-120 min or 24-48 h) reduces NF-κB phosphorylation levels and COX-2 expression in MDA-MB-231 cells[1].
FK-3000 (5.0 μg/mL; 120 min) effectively blocks NF-κB translocation from cytoplasm to nucleus in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
FK-3000 (10-25 mg/kg; p.o. for 10 d) significantly delays skin lesion, limits the development of further lesions and prolongs the mean survival time of HSV-1 infected mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1054312-81-0
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Masse moléculaire 417.45
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Formule C22H27NO7
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SMILES
COC1=C([C@]([H])(C2)NCC3)[C@]3(C4=C2C=CC(OC)=C4OC(C)=O)C[C@H](OC(C)=O)[C@@H]1O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Xu HD, et, al. FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. Int J Oncol. 2015;46(6):2309-16. [Content Brief]
[2]. Li YC, et, al. 6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation. Int J Oncol. 2015 Feb;46(2):578-86. [Content Brief]
[3]. Nawawi A, et, al. In vivo antiviral activity of Stephania cepharantha against herpes simplex virus type-1. Phytother Res. 2001 Sep;15(6):497-500. [Content Brief]
[4]. Lee JH, et, al. Development of a LC-MS method for quantification of FK-3000 and its application to in vivo pharmacokinetic study in drug development. J Pharm Biomed Anal. 2012 Nov;70:587-91. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FK-3000 Related Classifications
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