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Forimtamig

(Synonyms: RG-6234; RO-7425781)
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Forimtamig (RG-6324) is a GPRC5DxCD3 T-cell-engaging bispecific antibody. Forimtamig has a 2 + 1 format, comprising two high-affinity GPRC5D binding moieties and one CD3 binder. Forimtamig further features a P329G LALA mutated Fc domain that inhibits Fcγ receptor and C1q binding, yet retains binding to the neonatal Fc receptor. The isotype control for Forimtamig can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

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  • Pureté: 99.96%
  • CAS No.: 2649379-96-2
  • Masse moléculaire:169.38 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Forimtamig
  • Experimental Validation Results for Forimtamig
  • Experimental Validation Results for Forimtamig
  • Experimental Validation Results for Forimtamig
  • Experimental Validation Results for Forimtamig
  • Forimtamig Chemical Structure
    Forimtamig Chemical Structure
CAS No.: 2649379-96-2
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Forimtamig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    G1-K-L with domain crossover2

  • 1/16

    Flow Cytometry analysis of Jurkat cells labelling CD3E (red) with Forimtamig (anti-CD3E) (HY-P991055). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow cytometric analysis of 1X10^6 HUVEC cells labeling Forimtamig (HY-P991055, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, His, HY-P72726) can bind Forimtamig. The EC50 for this effect is 6.065 ng/mL.

  • 1/16

    Immobilized GPRC5D Protein-VLP, Human (HEK293, His HY-P77958) can bind Forimtamig. The EC50 for this effect is 17.58 ng/mL.

  • Forimtamig Chemical Structure
    1/16
  • Forimtamig
  • Flow Cytometry analysis of Jurkat cells labelling CD3E (red) with Forimtamig (anti-CD3E) (HY-P991055). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow cytometric analysis of 1X10^6 HUVEC cells labeling Forimtamig (HY-P991055, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, His, HY-P72726) can bind Forimtamig. The EC50 for this effect is 6.065 ng/mL.
  • Immobilized GPRC5D Protein-VLP, Human (HEK293, His HY-P77958) can bind Forimtamig. The EC50 for this effect is 17.58 ng/mL.
  • G1-K-L with domain crossover2