Ganoderic acid TR
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC50 values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses.
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- CAS No.: 862893-75-2
- Formule: C30H44O4
- Masse moléculaire:468.67
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 10.9 (H5N1), 4.6 μM (H1N1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
11 μM
Compound: 63
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 23092389] |
| Vero | IC50 |
>107 μM
Compound: 33
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Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay
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[PMID: 26716912] |
| Vero | IC50 |
>107 μM
Compound: 59
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Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
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[PMID: 28504879] |
Ganoderic acid TR (72 h) exhibits CC50 value of 91.6 μM against MCF-7 cells[1].
Ganoderic acid TR shows only weak antiviral activity against Oseltamivir-resistant pandemic influenza A (H1N1) virus and influenza B virus in MDCK cell-based assays, with low Selective Index (SI) values of 1.22 and 1.8, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 862893-75-2
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Appearance Solid
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Masse moléculaire 468.67
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Formule C30H44O4
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Color White to off-white
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SMILES
CC1(C)C(CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC/C=C(C)/C(O)=O)C[C@H](O)[C@](C)4C3=CC[C@@]12[H])=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 5.5 mg/mL (11.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1337 mL | 10.6685 mL | 21.3370 mL | 53.3424 mL |
| 5 mM | 0.4267 mL | 2.1337 mL | 4.2674 mL | 10.6685 mL | |
| 10 mM | 0.2134 mL | 1.0668 mL | 2.1337 mL | 5.3342 mL |
Ganoderic acid TR Related Classifications
HY-129150 Related Classifications
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