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Drd2 - dopamine receptor D2 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24318

About Drd2

Primary_assembly 8: 49,708,927-49,772,875 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 207 orthologues, 23 paralogues and is associated with 63 phenotypes. Biased expression in Brain (RPKM 22.7) and Adrenal (RPKM 6.).

Summary

Enables several functions, including dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and ionotropic glutamate receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of protein modification process. Located in several cellular components, including cytoplasmic vesicle; lateral plasma membrane; and perikaryon. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study Parkinsonism; cocaine dependence; and ovarian hyperstimulation syndrome. Biomarker of several diseases, including Gilles de la Tourette syndrome; drug psychosis; hyperprolactinemia; opiate dependence (multiple); and toxic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (Dopamine Receptor D2). [provided by Alliance of Genome Resources, Apr 2022]

Drd2 Products (2)

mRNA	Protein	Name
NM_001409379.1	NP_001396308.1	D(2) dopamine receptor isoform 2
NM_012547.3	NP_036679.1	D(2) dopamine receptor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables dopamine binding	IMP IMP: Inferred from mutant phenotype	17174299	RGD
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA IDA: Inferred from direct assay	2974511	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	15852061	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	20813060	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	17145509	RGD
enables organic cyclic compound binding	IPI IPI: Inferred from physical interaction	15852061	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10391935	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	22986162	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	17145509	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in G protein-coupled dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	12121979	RGD
involved in G protein-coupled receptor internalization	IDA IDA: Inferred from direct assay	14617818	RGD
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	17472703	RGD
involved in acid secretion	IDA IDA: Inferred from direct assay	8302280	RGD
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	12086672	RGD
involved in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	2410769	RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12086672	RGD
involved in auditory behavior	IMP IMP: Inferred from mutant phenotype	17142301	RGD
involved in autophagy	IDA IDA: Inferred from direct assay	26649942	RGD
involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	28710248	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	19853839	RGD
involved in drinking behavior	IDA IDA: Inferred from direct assay	12944496	RGD
involved in forebrain development	IMP IMP: Inferred from mutant phenotype	17175142	RGD
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	16530737	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	17118678	RGD
involved in negative regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	27638511	RGD
involved in negative regulation of circadian sleep/wake cycle, sleep	IDA IDA: Inferred from direct assay	12944496	RGD
involved in negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	15681393	RGD
involved in negative regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	16490190	RGD
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18216393	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	26277342	RGD
involved in negative regulation of synaptic transmission	IDA IDA: Inferred from direct assay	17314300	RGD
involved in negative regulation of voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	2162345	RGD
involved in orbitofrontal cortex development	IEP IEP: Inferred from expression pattern	22015925	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18809670	RGD
involved in positive regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18809670	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	20377617	RGD
involved in positive regulation of neurogenesis	IDA IDA: Inferred from direct assay	27638511	RGD
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	18809670	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12388421	RGD
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	15175382	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	15175382	RGD
involved in regulation of MAPK cascade	IDA IDA: Inferred from direct assay	12121979	RGD
involved in regulation of locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	22394078	RGD
involved in regulation of potassium ion transport	IDA IDA: Inferred from direct assay	2162345	RGD
involved in regulation of synapse structural plasticity	IDA IDA: Inferred from direct assay	22216301	RGD
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	8371717	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	19145071	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	19500946	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	28710248	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	18536982	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	15681393	RGD
involved in response to inactivity	IEP IEP: Inferred from expression pattern	17511973	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	19022977	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	19406037	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	19576243	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	1975644	RGD
involved in striatum development	IEP IEP: Inferred from expression pattern	22015925	RGD
involved in synapse assembly	IEP IEP: Inferred from expression pattern	10051231	RGD

Cellular Component GO Annotation	Evidence	Références	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	18340460	RGD
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	16924680	RGD
located in axon	IDA IDA: Inferred from direct assay	12965226	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	7623147	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12965226	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	7623147	RGD
located in endocytic vesicle	IDA IDA: Inferred from direct assay	14617818	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18340460	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	10391935	RGD
located in membrane	IDA IDA: Inferred from direct assay	8302280	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	12965226	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	18340460	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	18340460	RGD
located in sperm flagellum	IDA IDA: Inferred from direct assay	16924680	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	7623147	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd2 Protein Structure

7tmA_D2_dopamine_R

0
100
200
300
400
444 a.a.

Protein Preferred Names	Protein Names
D(2) dopamine receptor	dopamine receptor 2

Drd2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	Drd2	P61169	Ppp1r9b	Rattus norvegicus	O35274	Pull Down	10391935

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-13736A	Quinagolide hydrochloride		99.55%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-14423	Velneperit	Antagonist	98.25%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-N5074	Terrestrosin D		99.30%	Unkown
HY-120920	UNC9995	Agonist	99.93%	Unkown
HY-W040146	Propionylpromazine hydrochloride	Antagonist	99.71%	Unkown
HY-RS03997	DRD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-111480	Propionylpromazine	Antagonist	99.09%	Unkown
HY-W040146S	Propionylpromazine-d6 hydrochloride	Antagonist	99.78%	Unkown
HY-RS03998	Drd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03999	Drd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd2	NCBI	NCBI:1813