FRK - fyn related Src family tyrosine kinase Gene

Also Known as GTK; RAK; PTK5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2444

About FRK

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:115,931,149-116,100,725 (from NCBI)

This gene has 1 transcript (splice variant), 217 orthologues and 32 paralogues. Broad expression in kidney (RPKM 3.0), duodenum (RPKM 2.8) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

FRK Products (1)

mRNA Protein Name
NM_002031.3 NP_002022.1 tyrosine-protein kinase FRK

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
7664264 GOA
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
19345329 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
35723276 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12837246 GOA
Cellular Component GO Annotation Evidence Références Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
7696183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRK Protein Structure

SH3_1

SH3_1: SH3 domain (48 - 88)

SH2

SH2: SH2 domain (116 - 193)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (234 - 486)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase FRK

  • PTK5 protein tyrosine kinase 5

FRK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
FRK P42685 SF3B4 Homo sapiens Q15427
Validated Y2H
25416956
Intra
FRK P42685 SF3B4 Homo sapiens Q15427
Y2H Array
25416956
Intra
FRK P42685 RB1 Homo sapiens P06400
Pull Down
7664264
Intra
FRK P42685 RB1 Homo sapiens P06400
Anti Bait CoIP
7664264
Intra
FRK P42685 PTEN Homo sapiens P60484
Anti Bait CoIP
19345329
Intra
FRK P42685 PTEN Homo sapiens P60484
Anti Tag CoIP
19345329
Intra
FRK P42685 PTEN Homo sapiens P60484
Protein Kinase Assay
19345329
Intra
FRK P42685 BNIP2 Homo sapiens Q12982
Validated Y2H
32296183
Intra
FRK P42685 BNIP2 Homo sapiens Q12982
Y2H Prey Pooling
25416956
Intra
FRK P42685 BNIP2 Homo sapiens Q12982
Y2H
21516116
Intra
FRK P42685 BNIP2 Homo sapiens Q12982
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

FRK Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P84320 FRK Antibody (YA4017) WB, ELISA Human
HY-P84320A FRK Antibody (YA4017)(PBS only) WB, ELISA Human
HY-P85347 FRK Antibody (YA5039) IHC-P, ELISA Human
HY-P85347A FRK Antibody (YA5039)(PBS only) IHC-P, ELISA Human

Related Diseases

Diseases Alias
Co-Trimoxazole Allergy

  • Bactrim Allergy

  • Cotrimoxazol Allergy

  • Tmp/Smx Allergy

  • Trimethoprim/Sulfamethoxazole Allergy
Liver Benign Neoplasm

  • Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-E70725 FRK Recombinant Human Active Protein Kinase / Unkown
HY-RS05098 FRK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20681 Frk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27192 Frk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FRK VGNC VGNC:40978
Mus musculus FRK MGD MGI:103265
Bos taurus FRK VGNC VGNC:29112
Felis catus FRK VGNC VGNC:62358
Rattus norvegicus FRK RGD RGD:621423
Macaca mulatta FRK VGNC VGNC:72818
Others FRK NCBI