BLMH - bleomycin hydrolase Gene

Also Known as BH; BMH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 642

About BLMH

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,248,203-30,291,944 (from NCBI)

This gene has 13 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in skin (RPKM 54.6), placenta (RPKM 12.9) and 25 other tissues.

Summary

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the Glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for Cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]

BLMH Products (1)

mRNA Protein Name
NM_000386.4 NP_000377.1 bleomycin hydrolase

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables aminopeptidase activity EXP
EXP: Inferred from Experiment
9668046 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11350084 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
31875550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLMH Protein Structure

Peptidase_C1_2

Peptidase_C1_2: Peptidase C1-like family (6 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 455 a.a.
Protein Preferred Names Protein Names

bleomycin hydrolase

  • BLM hydrolase

BLMH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
BLMH Q13867 NUDT12 Homo sapiens Q9BQG2
Anti Tag CoIP
28514442
Intra
BLMH Q13867 NUDT12 Homo sapiens Q9BQG2
Validated Y2H
25910212
Intra
BLMH Q13867 NUDT12 Homo sapiens Q9BQG2
Y2H Bait-Prey Pool
25910212
Intra
BLMH Q13867 NUDT12 Homo sapiens Q9BQG2
Y2H Array
25910212
Intra
BLMH Q13867 NUDT12 Homo sapiens Q9BQG2
Y2H Prey Pooling
25416956
Intra
BLMH Q13867 NUDT12 Homo sapiens Q9BQG2
Anti Tag CoIP
33961781
Intra
BLMH Q13867 TNPO3 Homo sapiens Q9Y5L0
Validated Y2H
32296183
Intra
BLMH Q13867 PGLS Homo sapiens O95336
Y2H Prey Pooling
32296183
Intra
BLMH Q13867 TRIM47 Homo sapiens Q96LD4-2
Validated Y2H
32296183
Intra
BLMH Q13867 APP Homo sapiens P05067-4
Y2H
11350084
Intra
BLMH Q13867 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
BLMH Q13867 BLMH Homo sapiens Q13867
Y2H Prey Pooling
32296183
Intra
BLMH Q13867 BLMH Homo sapiens Q13867
Validated Y2H
32296183
Intra
BLMH Q13867 BLMH Homo sapiens Q13867
Y2H Array
32296183
Intra
BLMH Q13867 BLMH Homo sapiens Q13867
Y2H Array
25416956
Intra
BLMH Q13867 BLMH Homo sapiens Q13867
Y2H Pooling
16189514
Intra
BLMH Q13867 NTAQ1 Homo sapiens Q96HA8
Y2H Array
25416956
Intra
BLMH Q13867 BLMH Homo sapiens Q13867
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Testicular Germ Cell Cancer

  • Germ Cell Tumor Of Testis

  • Testicular Germ Cell Tumor

  • Testicular Germ Cell Neoplasm

  • Testicular Malignant Germ Cell Tumor
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS01521 BLMH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18230 Blmh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24709 Blmh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BLMH VGNC VGNC:26505
Macaca mulatta BLMH VGNC VGNC:70255
Mus musculus BLMH MGD MGI:1345186
Felis catus BLMH VGNC VGNC:60123
Canis familiaris BLMH VGNC VGNC:38465
Rattus norvegicus BLMH RGD RGD:1304668
Others BLMH NCBI