RAB29 - RAB29, member RAS oncogene family Gene

Also Known as RAB7L; RAB7L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8934

About RAB29

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,767,986-205,775,482 (from NCBI)

This gene has 9 transcripts (splice variants), 170 orthologues and 68 paralogues. Broad expression in kidney (RPKM 27.5), thyroid (RPKM 17.1) and 24 other tissues.

Summary

Enables several functions, including dynein complex binding activity; guanyl ribonucleotide binding activity; and Kinesin binding activity. Involved in several processes, including positive regulation of T cell receptor signaling pathway; positive regulation of receptor recycling; and toxin transport. Located in several cellular components, including Golgi apparatus; endosome; and vacuole. [provided by Alliance of Genome Resources, Apr 2022]

RAB29 Products (4)

mRNA Protein Name
NM_001135662.2 NP_001129134.1 ras-related protein Rab-7L1 isoform 1
NM_001135663.2 NP_001129135.1 ras-related protein Rab-7L1 isoform 2
NM_001135664.2 NP_001129136.1 ras-related protein Rab-7L1 isoform 3
NM_003929.3 NP_003920.1 ras-related protein Rab-7L1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables GDP binding IDA
IDA: Inferred from direct assay
24510904 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
24510904 GOA
enables dynein complex binding IDA
IDA: Inferred from direct assay
26021297 GOA
enables kinesin binding IPI
IPI: Inferred from physical interaction
26021297 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24510904 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
26021297 GOA
Biological Process GO Annotation Evidence Références Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
24510904 GOA
involved in T cell activation IMP
IMP: Inferred from mutant phenotype
26021297 GOA
involved in cellular detoxification IMP
IMP: Inferred from mutant phenotype
22042847 GOA
NOT involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
24788816 GOA
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
25767741 GOA
involved in modulation by host of viral process IMP
IMP: Inferred from mutant phenotype
19376974 GOA
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
24510904 GOA
involved in positive regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26021297 GOA
involved in positive regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
24788816 GOA
involved in positive regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
26021297 GOA
involved in protein localization to membrane IMP
IMP: Inferred from mutant phenotype
25767741 GOA
involved in response to bacterium IDA
IDA: Inferred from direct assay
22042847 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
24788816 GOA
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
26021297 GOA
Cellular Component GO Annotation Evidence Références Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
22042847 GOA
located in cis-Golgi network IDA
IDA: Inferred from direct assay
26021297 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
24788816 GOA
located in early endosome IDA
IDA: Inferred from direct assay
26021297 GOA
located in intracellular vesicle IDA
IDA: Inferred from direct assay
26021297 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
25767741 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
26021297 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
24510904 GOA
located in vacuole IDA
IDA: Inferred from direct assay
22042847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB29 Protein Structure

Ras

Ras: Ras family (9 - 174)

  • 0
  • 100
  • 203 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-7L1

  • RAB7, member RAS oncogene family-like 1

RAB29 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RAB29 O14966 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
RAB29 O14966 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra
RAB29 O14966 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
RAB29 O14966 LRRK2 Homo sapiens Q5S007
Pull Down
31552791
Intra
RAB29 O14966 LRRK2 Homo sapiens Q5S007
Confocal
24510904
Intra
RAB29 O14966 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
24510904
Intra
RAB29 O14966 LRRK2 Homo sapiens Q5S007
FPS
31552791
Intra
RAB29 O14966 TRIM27 Homo sapiens P14373
Validated Y2H
32296183
Intra
RAB29 O14966 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
RAB29 O14966 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
RAB29 O14966 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra
RAB29 O14966 LDOC1 Homo sapiens O95751
Validated Y2H
32296183
Intra
RAB29 O14966 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra
RAB29 O14966 LDOC1 Homo sapiens O95751
Y2H Array
31515488
Intra
RAB29 O14966 TRIM32 Homo sapiens Q13049
Y2H Prey Pooling
32296183
Intra
RAB29 O14966 TRIM32 Homo sapiens Q13049
Validated Y2H
32296183
Intra
RAB29 O14966 TRIM32 Homo sapiens Q13049
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RAB29 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P810951 RAB7L1 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Parkinson Disease 21

  • PARK21

  • Parkinson'S Disease 21

  • Parkinson Disease, Type 21
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Kufor-Rakeb Syndrome

  • Park9

  • Krppd

  • KRS

  • Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia

  • Autosomal Recessive Parkinson Disease 9

  • Parkinson Disease 9

  • Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset

  • Autosomal Recessive Juvenile Onset Parkinson Disease 9

  • Parkinson Disease Type 9

  • Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia

  • Park 9

  • Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis

  • Cln12 Disease

  • Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis

  • Parkinson Disease Autosomal Recessive 9
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11540 RAB29 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAB29 RGD RGD:620892
Mus musculus RAB29 MGD MGI:2385107
Macaca mulatta RAB29 VGNC VGNC:81528
Canis familiaris RAB29 VGNC VGNC:45270
Bos taurus RAB29 VGNC VGNC:33636
Felis catus RAB29 VGNC VGNC:97586
Others RAB29 NCBI