Griffipavixanthone
Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM).
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- CAS No.: 219649-95-3
- Formule: C36H28O12
- Masse moléculaire:652.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>10 μM
Compound: 16
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
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[PMID: 24960143] |
| L02 | IC50 |
>10 μM
Compound: 16
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Cytotoxicity against human HL7702 cells by MTT assay
Cytotoxicity against human HL7702 cells by MTT assay
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[PMID: 24960143] |
| MCF7 | IC50 |
>10 μM
Compound: 16
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Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
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[PMID: 24960143] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: 16
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Cytotoxicity against human MDA-MB-231 cells by MTT assay
Cytotoxicity against human MDA-MB-231 cells by MTT assay
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[PMID: 24960143] |
Chemical Information
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CAS No. 219649-95-3
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Masse moléculaire 652.60
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Formule C36H28O12
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SMILES
OC1=C(O)C(OC2=CC(O)=CC(O)=C2C3=O)=C3C4=C1[C@@H](C5=C6C(OC7=CC(O)=CC(O)=C7C6=O)=C(C(O)=C5)O)[C@@]8([H])[C@]4([H])C=C(C)CC8(C)C
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Synonyms
(+)-Griffipavixanthone
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lien Do TM, et al. Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana. Nat Prod Res. 2021 Nov;35(21):3613-3618. [Content Brief]
[2]. Shi JM, et al. Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules. 2014 Jan 27;19(2):1422-31. [Content Brief]
[3]. Ma Y, et al. Griffipavixanthone induces apoptosis of human breast cancer MCF-7 cells in vitro. Breast Cancer. 2019 Mar;26(2):190-197. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Griffipavixanthone Related Classifications
HY-N3974 Related Classifications
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