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Cat. No.: HY-P11811

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GUB10194

GUB10194 is a fully potent and selective GPR10 agonist with an EC₅₀ of 15 nM. GUB10194 does not significantly affect body weight or food intake.

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Formule: C₈₅H₁₄₈N₂₄O₂₃
Masse moléculaire:1874.23

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

GUB10194 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

GUB10194 is a fully potent and selective GPR10 agonist with an EC₅₀ of 15 nM. GUB10194 does not significantly affect body weight or food intake^[1].

IC₅₀ & Target^[1]

NPFF2-R

> 5000 nM (EC₅₀)

Voir tous les produits spécifiques à Isoform Neuropeptide FF Receptor :

In Vitro

GUB10194 (30 min) acts as a full, GPR10-selective agonist in Chem-1 cells expressing GPR10 (EC₅₀ = 15 nM), with no activity detected in CHO-K1 cells expressing NPFF2R (EC₅₀ > 5000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GUB10194 (1250 nmol/kg; s.c.; twice daily) does not produce significant body weight loss or food intake inhibition in diet-induced obese mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 5 weeks old at purchase, diet-induced obese)^[1]
Dosage:

1250 nmol/kg
Administration:

s.c.; twice daily
Result:

Did not significantly influence body weight or food intake during treatment or wash-out period.
Was detected in plasma samples collected 4 hours after the last dose on treatment day 6.

Chemical Information

Masse moléculaire 1874.23
Formule C₈₅H₁₄₈N₂₄O₂₃
Sequence

Ser-Arg-Gly-{Lys(AEEA-AEEA-γGlu-C18 diacid)}-Arg-Pro-Val-Gly-Arg-Phe-NH2
Sequence Shortening

SRG-{Lys(AEEA-AEEA-γGlu-C18 diacid)}-RPVGRF-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Alexopoulou F, et al. Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect. Sci Rep. 2022;12(1):1696. Published 2022 Feb 1. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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GUB10194

Voir tous les produits spécifiques à Isoform Neuropeptide FF Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

GUB10194 Related Classifications

HY-P11811 Related Classifications