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Cat. No.: HY-183859

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H142/08

H142/08 is a β1-adrenergic receptor-selective agonist. H142/08 induces concentration-dependent relaxation of isolated rat uterus and acts as a chronotropic stimulant to increase atrial rate, and its effects are effectively antagonized by Pafenolol (HY-165495). H142/08 also antagonizes the chronotropic effect of isoproterenol on isolated rat right atrium, but requires a higher proportion of receptor occupancy to produce sufficient stimulatory effects.

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CAS No.: 88017-05-4
Formule: C₂₂H₃₇N₃O₆
Masse moléculaire:439.55

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Please store the product under the recommended conditions in the Certificate of Analysis.

H142/08 Chemical Structure

CAS No.: 88017-05-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

IC₅₀ & Target^[1]

Beta-1 adrenergic receptor

8.97 (pKd)

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In Vitro

H142/08 binds to β₁-adrenoceptors in guinea-pig left ventricular free wall membranes with a pK_d of 8.97^[1].
H142/08 binds to β₂-adrenoceptors in guinea-pig soleus muscle membranes with a pK_d of 5.88^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 88017-05-4
Masse moléculaire 439.55
Formule C₂₂H₃₇N₃O₆
SMILES

O=C(N1CCOCC1)NCCNCC(COC2=CC=C(C=C2)OCCOCC(C)C)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Abrahamsson T, et al. Characterization of the beta 1-adrenoceptor stimulatory effects of the partial beta 1-agonists acebutolol, xamoterol, H142/08 and H201/70. Eur J Pharmacol. 1989;164(1):121-128. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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H142/08

Voir tous les produits spécifiques à Isoform Adrenergic Receptor

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H142/08 Related Classifications

HY-183859 Related Classifications