country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183766

Copy Link Print Information

HYF038

HYF038 is a blood-brain barrier-penetrant ligand of apoptosis signal-regulating kinase 1 (ASK1). When labeled with ¹¹C, HYF038 can be used for ASK1 neuroimaging studies.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₁₇H₁₄F₄N₆O₂
Masse moléculaire:410.33

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HYF038 Chemical Structure

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

HYF038 is a blood-brain barrier-penetrant ligand of apoptosis signal-regulating kinase 1 (ASK1). When labeled with ¹¹C, HYF038 can be used for ASK1 neuroimaging studies^[1].

Voir tous les produits spécifiques à Isoform Radionuclide-Drug Conjugates (RDCs) :

In Vivo

[¹¹C]HYF038 (0.04-0.4 mg/kg; intravenous injection via tail vein; single administration) exhibits a certain degree of BBB penetration, but shows low uptake; the high-dose blocking group presents a relatively high initial brain SUV followed by rapid washout^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (male, 6 months old)^[1]
Dosage:

0.04 mg/kg; 0.4 mg/kg
Administration:

i.v.; single dose 5 minutes pre-[¹¹C]HYF038
Result:

Showed [¹¹C]HYF038 brain uptake similar to baseline animals at 0.04 mg/kg dose.
Revealed a blocking effect in the 0.04 mg/kg dose group via normalized brain time-activity curves.
Demonstrated an initial [¹¹C]HYF038 brain uptake peak SUV of 1.3 followed by rapid washout at 0.4 mg/kg dose.

Chemical Information

Masse moléculaire 410.33
Formule C₁₇H₁₄F₄N₆O₂
SMILES

FC1=CN(C)C(C(C(NC2=NC(C3=NN=CN3[C@@H](C)C(F)(F)F)=CC=C2)=O)=C1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Huang Y, et al. The design, synthesis and evaluation of the first carbon-11 positron emission tomography radiotracer for ASK1 imaging. Bioorg Chem. 2026;178:109970. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

HYF038

Voir tous les produits spécifiques à Isoform Radionuclide-Drug Conjugates (RDCs)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

HYF038 Related Classifications

HY-183766 Related Classifications