KGP591
KGP591 is a tubulin polymerization inhibitor (IC50 0.57 µM). KGP591 induces significant G2/M stagnation, inhibits cell migration, disrupts microtubule structure and cell morphology in MDA-MB-231 cells. KGP591 shows antitumor activity in orthotopic model of kidney cancer (RENCA).
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- CAS No.: 3018962-69-8
- Formule: C24H21NO5
- Masse moléculaire:403.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | GI50 |
320 nM
Compound: KGP591
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Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 96 hrs by SRB assay
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[PMID: 37984295] |
| MDA-MB-231 | GI50 |
102 nM
Compound: KGP591
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Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 96 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 96 hrs by SRB assay
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[PMID: 37984295] |
KGP591 (100 nM, 72 h) inhibits migration and proliferation in MDA-MB-231 cells [1]>.
KGP591 (100 nM, 30 min) induces microtubule disruption in MDA-MB-231 cells[1].
KGP591 (200 nM, 48 h) shows G2/M cell cycle arrest in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:100 nM
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Incubation Time:72 h
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Result:Decreased in wound width in cells and remained largely open.
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Cell Line:MDA-MB-231 cells
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Concentration:200 nM
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Incubation Time:48 h
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Result:Had an arrest of MDA-MB-231 cells at G2/M of the cell cycle.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RENCA-luc xenograft in BALB/c mice[1]
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Dosage:150 mg/kg
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Administration:Subcutaneous Injection
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Result:Caused significant reduction of Bio-Layer Interferometry (BLI) signal occurred within 2.5 h.
Showed necrosis and severe hemorrhage in RENCA tumor tissue.
Chemical Information
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CAS No. 3018962-69-8
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Masse moléculaire 403.43
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Formule C24H21NO5
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SMILES
COC1=CC(C(C2=CNC3=CC(C4=CC=CC(O)=C4)=CC=C23)=O)=CC(OC)=C1OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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