Lethedioside A
Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC50 of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells.
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- CAS No.: 221289-31-2
- Formule: C29H34O15
- Masse moléculaire:622.57
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Stockage:
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
Hes1 9.5 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| KB | IC50 |
>100 μg/mL
Compound: 4
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Cytotoxicity against human KB cells after 72 hrs by neutral red assay
Cytotoxicity against human KB cells after 72 hrs by neutral red assay
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[PMID: 10075750] |
In Vitro
Lethedioside A (compound 4) weakly inhibits purified hTCF4/β-catenin complex formation in a cell-free ELISA with an IC50 of 46.9 μM[1].
Lethedioside A binds directly to GST-Hes1 immobilized on Sepharose beads in a cell-free biochemical binding assay[1].
Lethedioside A (24 h) potently inhibits LPS (HY-D1056)-induced nitric oxide production in RAW 264.7 macrophages with an IC50 of 7.91 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 221289-31-2
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Masse moléculaire 622.57
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Formule C29H34O15
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SMILES
O=C1C(C(OC(C2=CC(OC)=C(OC)C=C2)=C1)=CC(OC)=C3)=C3O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO[C@H]5[C@@H]([C@H]([C@H](O)CO5)O)O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lethedioside A Related Classifications
HY-N3393 Related Classifications
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