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Lexosiran

Lexosiran is a siRNA that inhibits ANGPTL3 (angiopoietin-related protein 3) synthesis, and can be use for the study of antihyperlipidaemic.

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  • Lexosiran Chemical Structure
    Lexosiran Chemical Structure
CAS No.: 3078403-66-1
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Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • Lexosiran Chemical Structure
    Lexosiran Chemical Structure RNA, ([1′-de(6-amino-9H-purin-9-yl)]A-(5′→5′)-sp-Gm-Am-Am-Um-Gm-Gm-Am-Am-(2′-deoxy-2′-fluoro)G-Gm-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)A-Um-Am-Cm-Um-Cm-Um-Am-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-9-yl)]A), 3′-[O-[1-[18-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-6,10-bis[2-[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]-2-oxoethyl]-1,5,12-trioxo-16-oxa-6,10,13-triazaoctadec-1-yl]-4-piperidinyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)U-sp-Am-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-Am-Um-Am-Am-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)C-Cm-Am-Um-sp-Um-sp-Cm) (1:1)
    1/16
  • RNA, ([1′-de(6-amino-9H-purin-9-yl)]A-(5′→5′)-sp-Gm-Am-Am-Um-Gm-Gm-Am-Am-(2′-deoxy-2′-fluoro)G-Gm-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)A-Um-Am-Cm-Um-Cm-Um-Am-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-9-yl)]A), 3′-[O-[1-[18-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-6,10-bis[2-[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]-2-oxoethyl]-1,5,12-trioxo-16-oxa-6,10,13-triazaoctadec-1-yl]-4-piperidinyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)U-sp-Am-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-Am-Um-Am-Am-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)C-Cm-Am-Um-sp-Um-sp-Cm) (1:1)