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Margetuximab

(Synonyms: MGAH-22)
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Based on 1 Customer Validation

Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer.

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  • Pureté: ≥99.0%
  • CAS No.: 1350624-75-7
  • Masse moléculaire:146.1 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Margetuximab
  • Experimental Validation Results for Margetuximab
  • Experimental Validation Results for Margetuximab
  • Margetuximab Chemical Structure
    Margetuximab Chemical Structure
CAS No.: 1350624-75-7
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Margetuximab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Margetuximab on AHC2 biosensor, can bind HER2/CD340 Protein, Human (HEK293, His, HY-P70254) with an affinity constant of 5.604E-10 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Margetuximab (HY-P99030, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Margetuximab Chemical Structure
    1/16
  • Margetuximab
  • Loaded Margetuximab on AHC2 biosensor, can bind HER2/CD340 Protein, Human (HEK293, His, HY-P70254) with an affinity constant of 5.604E-10 M as determined in BLI assay.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Margetuximab (HY-P99030, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).