country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-14361

Copy Link Print Information

MK-4965

MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 920035-77-4
Formule: C₂₀H₁₃Cl₂N₅O₂
Masse moléculaire:426.26

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MK-4965 Chemical Structure

CAS No.: 920035-77-4

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC50: 0.23 nM (WT), 0.39 nM (Y181C), 0.40 nM (K103N)^[1]

Voir tous les produits spécifiques à Isoform HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human HL60 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human HL60 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Macrophage	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human macrophage after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human macrophage after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Macrophage	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human macrophage after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human macrophage after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Monocyte	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human monocyte after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human monocyte after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Monocyte	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human monocyte after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human monocyte after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
MT4	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human MT4 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human MT4 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
PBMC	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human PBMC after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human PBMC after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
PBMC	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human PBMC after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human PBMC after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
SUP-T1	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human SupT1 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human SupT1 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
T-cell	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human CD4+ T cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human CD4+ T cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
T-cell	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human CD4+ T cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human CD4+ T cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]

Chemical Information

CAS No. 920035-77-4
Masse moléculaire 426.26
Formule C₂₀H₁₃Cl₂N₅O₂
SMILES

N#CC1=CC(Cl)=CC(OC2=CC(OCC3=NNC4=NC(N)=CC=C43)=CC=C2Cl)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lai MT, et al. Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Jun;53(6):2424-31. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

MK-4965

Voir tous les produits spécifiques à Isoform HIV

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

MK-4965 Related Classifications

HY-14361 Related Classifications