MOR modulator-1

MOR modulator-1 (10 mg/kg, warm-water tail immersion, 20min) containing a 2’- thiazolyl moiety acts as the most potent member in this series of NAT analogs in antagonizing morphine mediated antinociception effect^[1].
MOR modulator-1 (10 mg/kg, warm-water tail immersion, 20 min) shows AD₅₀ value of 0.043 mg/kg, 10 times more potent compared to NAT^[1].
MOR modulator-1 (10 mg/kg, warm-water tail immersion, 20 min) stands out as the most active expoxymorphinan-based molecule among all MOR modulators^[1].
MOR modulator-1 (0.05-10 mg/kg, s.c., 20 min) exhibits fewer wet dog shakes and paw tremors at all testing doses than 1 mg/kg naloxone (NLX), even at the highest doses of 5 mg/kg and 10mg/kg, respectively^[1].
MOR modulator-1 (5 mg/kg, s.c., 20 min) mean count values in wet dog shake, jumps and paw tremors are 9.8, 36.8 and 30.2, respectively^[1].
MOR modulator-1 in brain at 5, 10, and 30 min after administration were 0.187, 0.235, and 0.264 μg/g, respectively, revealing that MOR modulator-1 quickly penetrated into the brain after s.c. administration and remained in the brain for a long time^[1].