NOS-IN-2
NOS-IN-2 (Compound 4i) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 20 µM, without inhibiting eNOS. NOS-IN-2 has little toxicity and can be used for studying inflammatory disorders.
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- CAS No.: 2766146-79-4
- Formule: C18H20F3N3O2
- Masse moléculaire:367.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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iNOS 20 μM (IC50) |
nNOS >1000 μM (IC50) |
In Vitro
NOS-IN-2 (Compound 4i) shows high iNOS selectivity without eNOS inhibition activity [1].
NOS-IN-2 (0-100 µM, 30 min) has little toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:HUVECs
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Concentration:10, 20, 50, 100, 500 µM
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Incubation Time:30 min
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Result:Had little toxicity, only at the concentration above 100 µM, the cell viability was significantly (approximately 20%) reduced.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2766146-79-4
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Masse moléculaire 367.37
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Formule C18H20F3N3O2
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SMILES
COC1=CC=C(C(C(CCNC(C2=CC=C(C=C2)C(F)(F)F)=N)O)=C1)N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOS-IN-2 Related Classifications
HY-115916 Related Classifications
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