NS3763
NS3763 is a selective and noncompetitive GLUK5 receptor antagonist with an IC50 of 1.6 µM. NS3763 does not show significant antagonistic properties on GLUK6, AMPA or NMDA receptors.
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- CAS No.: 70553-45-6
- Formule: C22H16N2O6
- Masse moléculaire:404.37
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
IC50: 1.6 µM (GLUK5 receptor)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.6 μM
Compound: NS-3763
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In vitro inhibitory activity against human ionotropic glutamate receptor ionotropic kainate 1 (GluR-5) expressed in HEK293 cells.
In vitro inhibitory activity against human ionotropic glutamate receptor ionotropic kainate 1 (GluR-5) expressed in HEK293 cells.
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[PMID: 14667236] |
In human embryonic kidney HEK293 cells expressing homomeric GLUK5 or GLUK6 receptors, NS3763 displays selectivity for inhibition of domoate-induced increase in intracellular calcium mediated through the GLUK5 subtype (IC50 = 1.6 µM) of kainate receptors compared with the GLUK6 subtype (IC50 > 30 µM)[1].
NS3763 selectively inhibits l-glutamate- and domoate-evoked currents through GLUK5 receptors in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 70553-45-6
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Masse moléculaire 404.37
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Formule C22H16N2O6
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SMILES
O=C(C1=C(NC(C2=CC=CC=C2)=O)C=C(NC(C3=CC=CC=C3)=O)C(C(O)=O)=C1)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NS3763 Related Classifications
HY-107603 Related Classifications
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