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Cat. No.: HY-144444

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NSC381467

NSC381467 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC381467 has strong antiproliferative activities. NSC381467 has the potential for the research of cancer diseases.

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CAS No.: 1033006-96-0
Formule: C₂₀H₁₆O₇
Masse moléculaire:368.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NSC381467 Chemical Structure

CAS No.: 1033006-96-0

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	6.04 μM Compound: NSC381467	Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay	[PMID: 34995690]
HeLa	IC₅₀	1.74 μM Compound: NSC381467	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay	[PMID: 34995690]

Chemical Information

CAS No. 1033006-96-0
Masse moléculaire 368.34
Formule C₂₀H₁₆O₇
SMILES

COC1=CC=CC2=C1C(C3=C(C4=C([C@H]([C@@H]3O)O)C=C(C=C4O)CO)C2=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jiwacharoenchai N, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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NSC381467

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

NSC381467 Related Classifications

HY-144444 Related Classifications