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Ontorpacept

(Synonyms: TTI-621)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity.

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  • Pureté : 99.57%
  • CAS No.: 2131089-46-6
  • Masse moléculaire:76.43 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Ontorpacept
  • Experimental Validation Results for Ontorpacept
  • Ontorpacept Chemical Structure
    Ontorpacept Chemical Structure
CAS No.: 2131089-46-6
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609-228-6898
[email protected] [email protected]
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Assay Types
  • 1/16

    Homo sapiens SIRPA (signal regulatory protein alpha, SHPS1, SIRP, SIRPalpha)-IGHG1 (Fc (Fragment constant)

  • 1/16

    Immobilized Ontorpacept can bind Human CD47 Protein (ECD, His Tag). The EC50 for this effect is 9.12 ng/mL.

  • Ontorpacept Chemical Structure
    1/16
  • Ontorpacept
  • Immobilized Ontorpacept can bind Human CD47 Protein (ECD, His Tag). The EC50 for this effect is 9.12 ng/mL.
  • Homo sapiens SIRPA (signal regulatory protein alpha, SHPS1, SIRP, SIRPalpha)-IGHG1 (Fc (Fragment constant)