Penitrem B
Penitrem B (Tremortin B) is a dechlorinated indole diterpene tremorgen found in fungi such as Penicillium palitans and Aspergillus sulphureus. Penitrem B induces tremors, ataxia, and convulsions in mice. Penitrem B is used in research related to tremogenic mycotoxicosis and fungal infections.
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- CAS No.: 11076-67-8
- Formule: C37H45NO5
- Masse moléculaire:583.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Penitrem B exhibits weak or no cytotoxic activity against A549 and HL-60 cell lines[1].
Penitrem B is obtained by extraction and purification from Fernbach cultures of Penicillium palitans NRRL 3468, with a yield of approximately 25 mg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (18-24 g)[2]
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Dosage:1.38, 2.76, 5.52 and 11.04 mg/kg
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Administration:i.p.; single dose
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Result:Caused perceptible tremors at doses as low as 1.3 mg/kg which persisted for several hours.
Caused 3 deaths out of 4 animals at 5.52 mg/kg.
Caused 4 deaths out of 4 animals at 11.04 mg/kg.
Calculated an LD50 of 5.84 mg/kg with a 95% confidence interval of 4.13 to 8.26 mg/kg.
Chemical Information
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CAS No. 11076-67-8
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Masse moléculaire 583.76
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Formule C37H45NO5
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SMILES
O[C@]12[C@]34[C@]([C@H]([C@H](O[C@]4([H])CC[C@@]1([C@]5(C6=C7[C@](OC(C)([C@]8([H])[C@@]9([H])C%10=C7C(N6)=CC=C%10CC([C@@]9([H])C8)=C)C)([H])[C@]5([H])CC2)C)C)C(C)=C)O)([H])O3
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Synonyms
Tremortin B
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Structure Classification
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Initial Source
Penicillium crustosum
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gao SS, et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189. J Nat Prod. 2016 Aug 26;79(8):2066-74. [Content Brief]
[4]. Moldes-Anaya A, et al. Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon : official journal of the International Society on Toxinology. 2012 Dec 15;60(8):1428-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penitrem B Related Classifications
HY-N22059 Related Classifications
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