Phlorizin (Standard)
Based on 1 publication(s) in Google Scholar
Phlorizin (Floridzin) (Standard) is the analytical standard of Phlorizin. This product is intended for research and analytical applications. Phlorizin is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities.
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- Pureté : 98%
- CAS No.: 60-81-1
- Formule: C21H24O10
- Masse moléculaire:436.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Phlorizin (Standard)
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 60-81-1
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Masse moléculaire 436.41
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Formule C21H24O10
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SMILES
O=C(C1=C(O)C=C(O)C=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)CCC3=CC=C(O)C=C3
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Synonyms
Floridzin (Standard)
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phlorizin (Standard) Related Classifications
HY-N0143R Related Classifications
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Keywords
- Phlorizin (Standard)
- 60-81-1
- Floridzin (Standard)
- NF-κB
- Reference Standards
- GLUT
- Bacterial
- Akt
- DNA/RNA Synthesis
- JAK
- Apoptosis
- mTOR
- PI3K
- Caspase
- STAT
- SGLT
- Nuclear factor-κB
- Nuclear factor-kappaB
- Glucose transporter
- PKB
- Protein kinase B
- Janus kinase
- Mammalian target of Rapamycin
- Phosphoinositide 3-kinase
- Sodium-dependent glucose cotransporters
- Inhibitor
- inhibitor
- inhibit