Phoyunnanin E
Phoyunnanin E, isolated from Dendrobium venustum, possesses anti-migration activity. Phoyunnanin E can be used for the research of cancer.
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- CAS No.: 886747-60-0
- Formule: C30H26O6
- Masse moléculaire:482.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Phoyunnanin E (0~10 μM; 48 hours; H460 cells) decreases cell migration through integrin downregulation[1].
Phoyunnanin E (0~100 μM; 24 and 48 hours; H460 cells) shows that the proliferation rate of treated cells have significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 hours[1].
Phoyunnanin E (0~100 μM; 24 hours; H460 cells) induces cytotoxic effects at the concentrations from 50 to 100 μM and induces a significant increase in apoptotic and necrotic cells at 20~100 μM[1].
Phoyunnanin E (0~10 μM; 48 hours; H460, H292 and A549 cells) significantly decreases the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner[1].
Phoyunnanin E attenuates anchorage-independent growth and migration of lung cancer H460 cells. Phoyunnanin E significantly inhibits cell migration across the wound space at the concentrations of 5 and 10 μM, at 24 h and 48 h, compared to the non-treated control. Phoyunnanin E (0~10 μM; 48 hours) exhibits a significant decrease in filopodia numbers at the protrusion edges of the cells in a dose-dependent manner. Phoyunnanin E decreases cancer cell migration in other human lung cancer cells. Phoyunnanin E decreases cancer cell invasion. Phoyunnanin E suppresses epithelial-mesenchymal transition (EMT). Phoyunnanin E down-regulates integrins αv and β3 and the regulatory proteins in cell migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H460 cells
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Concentration:1~10 μM
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Incubation Time:48 hours
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Result:Decreased cell migration through integrin downregulation.
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Cell Line:H460 cells
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Concentration:0~100 μM
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Incubation Time:24 and 48 hours
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Result:The proliferation rate of treated cells had significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 h.
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Cell Line:H460 cells
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Concentration:0~100 μM
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Incubation Time:24 hours
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Result:Induced a significant increase in apoptotic and necrotic cells at 20~100 μM.
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Cell Line:H460 cells
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Concentration:0~100 μM
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Incubation Time:24 hours
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Result:Induced cytotoxic effects at the concentrations from 50 to 100 μM.
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Cell Line:H460, H292 and A549 cells
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Concentration:0~10 μM
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Incubation Time:48 hours
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Result:Significantly decreased the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner.
Chemical Information
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CAS No. 886747-60-0
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Masse moléculaire 482.52
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Formule C30H26O6
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SMILES
OC1=CC=C2C(CCC3=C(C(OC)=CC(O)=C23)OC4=CC=C5C(CCC6=CC(OC)=CC(O)=C56)=C4)=C1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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