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Cat. No.: HY-119126

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PK-3

PK-3 is a cancer cell growth inhibitor with microtubule-binding activity. PK-3 binds to tubulin, disrupts the intracellular microtubule network required for mitosis, and induces cell death. PK-3 can be used in research related to chronic myeloid leukemia.

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CAS No.: 932331-38-9
Formule: C₂₁H₂₀N₂O₃S
Masse moléculaire:380.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PK-3 Chemical Structure

CAS No.: 932331-38-9

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.049 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 27423028]
HepG2	IC₅₀	0.029 μM Compound: 1	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 27423028]
HT-1080	EC₅₀	<100 nM Compound: 3, CID 20959075	Growth inhibition of human HT1080 cells after 24 hrs by alamar blue assay Growth inhibition of human HT1080 cells after 24 hrs by alamar blue assay	[PMID: 22247791]
MCF-10A	EC₅₀	<100 nM Compound: 3, CID 20959075	Growth inhibition of human MCF10A cells after 24 hrs by alamar blue assay Growth inhibition of human MCF10A cells after 24 hrs by alamar blue assay	[PMID: 22247791]
PC-3	IC₅₀	0.038 μM Compound: 1	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 27423028]
SK-OV-3	IC₅₀	0.047 μM Compound: 1	Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay	[PMID: 27423028]

In Vitro

PK-3 (18-55 nM; 10 to 21 days) induces a form of non-apoptotic cell death that is distinct from ferroptosis in KBM7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human chronic myeloid leukemia KBM7 cells
Concentration:

55 nM (initial screening for colony outgrowth); 18 nM (final estimated after 3-day initial incubation with growth medium dilution)
Incubation Time:

10 to 21 days
Result:

Induced a non-ferroptotic form of non-apoptotic cell death in KBM7 cells.
Yielded no significantly enriched genes with gene trap insertions in PK-3-resistant KBM7 colonies.

Chemical Information

CAS No. 932331-38-9
Masse moléculaire 380.46
Formule C₂₁H₂₀N₂O₃S
SMILES

O=S(N1CCCC2=C1C=CC=C2)(C3=CC=C(C=C3)C4=CN=C(O4)C5CC5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Dixon SJ, et al. Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. ACS Chem Biol. 2015;10(7):1604-1609. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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