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Cat. No.: HY-111147

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RDEA-427

RDEA-427 is a pyrrolopyrimidine derivative and also a HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). RDEA-427 acts on wild-type and NNRTI-resistant mutant HIV-1. RDEA-427 can be used in research related to HIV infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 914496-19-8
Formule: C₂₂H₁₆N₆O
Masse moléculaire:380.41

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Please store the product under the recommended conditions in the Certificate of Analysis.

RDEA-427 Chemical Structure

CAS No.: 914496-19-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target^[1]

HIV-1

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Cellular Effect

Cell Line	Type	Value	Description	References
MT4	EC₅₀	0.9 nM Compound: RDEA427	Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25707013]

In Vitro

RDEA-427 (for 5 days) potently inhibits the replication of wild-type HIV-1 in MT4 cells, with an EC₅₀ of 0.9 nM and SI >50,000^[1].
RDEA-427 (for 5 days) inhibits the replication of NNRTI-resistant HIV-1^K103N-Y181C mutant strain in MT4 cells, and the EC₅₀ value against this mutant was 11‑fold higher than that against the wild‑type strain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 914496-19-8
Masse moléculaire 380.41
Formule C₂₂H₁₆N₆O
SMILES

N#CC1=CC=C(C=C1)NC=2N=C(OC=3C(=CC(C#N)=CC3C)C)C=4C=CNC4N2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Tian Y, et al. Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives. Bioorg Med Chem. 2014 Apr 1;22(7):2052-9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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RDEA-427

Voir tous les produits spécifiques à Isoform HIV