Schisanchinin D
Schisanchinin D is an NO release inhibitor found in the fruits of Schisandra chinensis. Schisanchinin D can inhibit the release of nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia in primary murine BV2 microglia cells. Schisanchinin D is promising for research of neurodegenerative diseases such as Alzheimer's disease (AD).
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- CAS No.: 1614245-13-4
- Formule: C23H30O6
- Masse moléculaire:402.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Description
Chemical Information
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CAS No. 1614245-13-4
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Masse moléculaire 402.48
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Formule C23H30O6
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SMILES
OC1=C(OC)C(OC)=CC2=C1C3=C(OC)C(OC)=C(OC)C=C3C[C@H](C)[C@H](C)C2
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Pureté et documentation
Références
[1]. Hu D, et al. Dibenzocyclooctadiene lignans from Schisandra chinensis and their inhibitory activity on NO production in lipopolysaccharide-activated microglia cells. Phytochemistry. 2014 Aug;104:72-8. [Content Brief]
[2]. Jafernik K, et al. Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology. Chin Med. 2024 Jan 24;19(1):17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)