slCeMM1
slCeMM1 is a selective SLC16A3 (MCT4) inhibitor. slCeMM1 inhibits lactate transport, induces intracellular lactate accumulation, reduces viability of SLC16A3-dependent cells, and inhibits growth of SLC16A3-dependent cells. slCeMM1 can be used for the research of rheumatoid arthritis and cancer.
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- CAS No.: 949973-22-2
- Formule: C20H17F3N6O
- Masse moléculaire:414.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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MCT4 |
slCeMM1 (serial dilutions; 72 h) potently and selectively inhibits viability of SLC16A3-dependent HAP1 SLC16A1-/- cells with an IC50 of 0.88 μM, while having no effect on HAP1 cells dependent on SLC16A1, SLC16A7, or SLC16A8[1].
slCeMM1 (serial dilutions; 6 h) induces intracellular lactate accumulation in SLC16A3-dependent HAP1 SLC16A1-/- cells with an IC50 of 91 nM, confirming inhibition of SLC16A3-mediated lactate export[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 949973-22-2
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Masse moléculaire 414.38
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Formule C20H17F3N6O
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SMILES
O=C(CCC1=C(C)N2N=C(C(F)(F)F)N=C2N=C1C)NC3=CN=C4C=CC=CC4=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
slCeMM1 Related Classifications
HY-182416 Related Classifications
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