Steffimycin B
Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s=3.5, 6.75, 3.28, and 10.5 μM, respectively). It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 μg/mL), and P. falciparum (IC50=2.19 μM).
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- CAS No.: 54526-94-2
- Formule: C29H32O13
- Masse moléculaire:588.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.8 μM
Compound: 9
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
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[PMID: 38412432] |
| PC-3 | IC50 |
3.1 μM
Compound: 9
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
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[PMID: 38412432] |
Chemical Information
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CAS No. 54526-94-2
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Masse moléculaire 588.56
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Formule C29H32O13
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SMILES
OC1=C(C(C2=C3O)=O)C(C(C2=CC(OC)=C3)=O)=CC(C4=O)=C1[C@H]([C@@H]([C@](O)4C)OC)O[C@H](O[C@H]5C)[C@@H]([C@@H]([C@H]5OC)O)OC
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Synonyms
NSC 204855; U 40615
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Steffimycin B Related Classifications
HY-N8470 Related Classifications
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