T1742
T1742 is an autophagy inhibitor targeting ATG5. T1742 blocks and disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR.T 1742 inhibits autophagy in living cells via reduced autophagosome formation and downregulated ATG8-PE conjugation. T1742 can be used to study autophagy mechanisms.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2841473-81-0
- Formule: C24H18N2O6
- Masse moléculaire:430.41
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
T1742 (2.5-40 μM; 16 h) dose-dependently inhibits autophagy in COS-7 cells[1].
T1742 (1.25-40 μM; 6 h) dose-dependently reduces LC3-II levels, indicating autophagy inhibition, in COS-7, U-937, and THP-1 cells[1].
T1742 blocks the ATG5-ATG16L1 and ATG5-TECAIR protein-protein interactions in vitro with IC50 values of 1.1 μM and 1.7 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:COS-7
-
Concentration:2.5; 5; 10; 20; 40 μM
-
Incubation Time:16 h
-
Result:Caused a dose-dependent left shift in LC3 fluorescence intensity, indicating autophagy inhibition.
-
Cell Line:COS-7, U-937, THP-1
-
Concentration:1.25; 2.5; 5; 10; 20 μM (COS-7 cells); 5; 10; 20; 40 μM (U-937 and THP-1 cells)
-
Incubation Time:6 h
-
Result:Reduced the LC3-II/β-actin ratio from 1.01 at 1.25 μM to 0.64 at 20 μM in COS-7 cells.
Caused a significant dose-dependent decrease in LC3-II protein levels in U-937 and THP-1 cells.
Chemical Information
-
CAS No. 2841473-81-0
-
Masse moléculaire 430.41
-
Formule C24H18N2O6
-
SMILES
OC(CCN1C(C2=CC=CC=C2)=C/C(C1=O)=C\C3=CC=C(C4=CC=C(C=C4)[N+]([O-])=O)O3)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Xiang H, et al. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein-Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 23;66(4):2457-2476. [Content Brief]
[2]. Xiang H, et al. Discovery of small-molecule inhibitors for the protein-protein interactions involving ATG5. Autophagy Rep. 2023;2(1):2215617. Published 2023 May 27. [Content Brief]
[3]. Yan D, et al. Molecular dynamics-driven drug discovery. Phys Chem Chem Phys. 2025;27(24):12633-12651. Published 2025 Jun 18. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T1742 Related Classifications
HY-183807 Related Classifications
Powered by Bioz