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Cat. No.: HY-118528

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TP0427736

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

TP0427736 is a selective inhibitor of ALK5 with an IC₅₀ of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells.

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CAS No.: 864374-00-5
Formule: C₁₄H₁₀N₄S₂
Masse moléculaire:298.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

TP0427736 Chemical Structure

CAS No.: 864374-00-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- Cellular Effect
Chemical Information
Publications (2)
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform TGF-β Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8.7 nM Compound: 3a	Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 hr by fluorescence analysis Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 hr by fluorescence analysis	[PMID: 23117174]

Chemical Information

CAS No. 864374-00-5
Masse moléculaire 298.39
Formule C₁₄H₁₀N₄S₂
SMILES

CC1=CSC(C2=C(NC=N2)C3=CC=C4N=CSC4=C3)=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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J Clin Invest

Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communications. [Abstract]

2024 Jun 18;134(16):e178303. PMID: 38889010
Commun Biol

Wnt11 mediates fibroblast-smooth muscle cell interaction to promote neurogenic bladder fibrosis in rats. [Abstract]

2026 Feb 9;9(1):194. PMID: 41663583

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TP0427736

2 Cited Publications

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TP0427736

Publications Citing Use of MedChemExpress (MCE) TP0427736

Voir tous les produits spécifiques à Isoform TGF-β Receptor

Activité biologique

Chemical Information

Publications (2)

Pureté et documentation

Références

Calculators

Help & FAQs

TP0427736 Related Classifications

HY-118528 Related Classifications