Copy Link Print Information

UK-5099

(Synonyms: PF-1005023)
56 Cited Publications
Avis client

Based on 56 publication(s) in Google Scholar

UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

  • Pureté: 99.95%
  • CAS No.: 56396-35-1
  • Formule: C18H12N2O2
  • Masse moléculaire:288.30
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • UK-5099 Chemical Structure
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • UK-5099 Chemical Structure
    UK-5099 Chemical Structure
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
CAS No.: 56396-35-1
Size
Prix
Stock
Quantité
Amount: USD 0.00
Please select quantity
or
or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
  • Activité biologique
  • Chemical Information
  • Solvant et solubilité
  • Protocole
  • Pureté et documentation
  • Références
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) UK-5099

More
Customer Validation & Images
Cell Proliferation/Viability AssayFlow CytometryWB
  • Flow Cytometry
  • Flow Cytometry
  • WB
  • WB
  • Cell Proliferation/Viability Assay
Keywords
100 mg

Obtenir un devis En stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Enregistrer
Sign in to MedChemExpress
Enregistrer un nouveau compte

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • UK-5099 Chemical Structure
    UK-5099 Chemical Structure
    1/16
  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 15;16(1):4502. [Abstract]

    Customer Validation
     Naive Tigit−/− or Tigit+/+ CD4+ T cells were cultured under Th1- or Th17- polarizing condition for 5 d. UK5099 (20 μM), MSDC-0602 (10 μM), Etomoxir (ETO, 1 μM), or bis-2-(5-phenylacetamido-1, 2, 4-thiadiazol-2-yl) ethyl sulfide (BPTES, 3 μM) was included for the last 48 h of culture. IFNγ, T-bet, IL-17A, and RORγt expression in CD4+ T cells were measured by flow cytometry.

  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 15;16(1):4502. [Abstract]

    Customer Validation
     Naive Tigit−/− or Tigit+/+ CD4+ T cells were cultured under Th1- or Th17- polarizing condition for 5 d. UK5099 (20 μM), MSDC-0602 (10 μM), Etomoxir (ETO,1 μM), or bis-2-(5-phenylacetamido-1, 2,4-thiadiazol-2-yl) ethyl sulfide (BPTES, 3 μM) was included for the last 48 h of culture. IFNγ, T-bet, IL-17A, and RORγt expression in CD4+ T cells were measured by flow cytometry.

  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 15;16(1):4502. [Abstract]

    Customer Validation
     CD4+ T cells from HC or PM patients were stimulated with αCD3/CD28 in the presence of UK5099 (20 μM), recombinant human CD155-Fc (10 μg/ml), or control IgG1 for 3 d.

  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 15;16(1):4502. [Abstract]

    Customer Validation
     Immunoblot analysis of acetylated H3K9 and H3K27 in mouse CD4+ T cells and representative bands.Cells were stimulated with αCD3/CD28 for 3 days in the presence of UK5099 (20 μM), ETO, or BPTES.

  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 3;15(1):6587. [Abstract]

    Customer Validation
     NIC cells were treated with 10μM UK5099, or DMSO as a control. Proliferation was assessed by Incucyte® to measure cell confluency in real time.

  • UK-5099