Verdamicin
Verdamicin is an aminoglycoside antibiotic isolated from Micromonospora grisea, exhibiting broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria. Verdamicin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Verdamicin exerts bactericidal effects against Gram-negative and Gram-positive isolates. Verdamicin can be used for research on bacterial infections.
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- CAS No.: 49863-48-1
- Formule: C20H39N5O7
- Masse moléculaire:461.55
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Activité biologique
Description
Verdamicin is an aminoglycoside antibiotic isolated from Micromonospora grisea, exhibiting broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria. Verdamicin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Verdamicin exerts bactericidal effects against Gram-negative and Gram-positive isolates. Verdamicin can be used for research on bacterial infections[1][2][3][4].
In Vitro
Bacterial Infection
Verdamicin (0.25-16 μg/mL; 18 h) is highly active against non-Gentamicin (HY-A0276A)-resistant E. coli, with an MIC90 of 0.5 μg/mL and 98.1% susceptibility[1].
Verdamicin (0.125-128 μg/mL; 18 h) is highly active against non-Gentamicin-resistant K. pneumoniae, with an MIC90 of 0.5 μg/mL and 98.8% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant E. cloacae, with an MIC90 of 0.5 μg/mL and 98.2% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant E. aerogenes, with an MIC90 of 1 μg/mL and 98.1% susceptibility[1].
Verdamicin (0.25-0.5 μg/mL; 18 h) is highly active against non-Gentamicin-resistant C. diversus, with an MIC90 of 0.5 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is highly active against non-Gentamicin-resistant P. mirabilis, with an MIC90 of 2 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) is highly active against non-Gentamicin-resistant S. marcescens, with an MIC90 of 0.5 μg/mL and 96.3% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant S. marcescens, with an MIC90 of >128 μg/mL and 10.0% susceptibility[1].
Verdamicin (0.5-4 μg/mL; 18 h) is highly active against non-Gentamicin-resistant M. morganii, with an MIC90 of 2 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25-128 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant C. freundii, with an MIC90 of 64 μg/mL and 72.2% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is active against non-Gentamicin-resistant P. rettgeri, with an MIC90 of 8 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant A. calcoaceticus, with an MIC90 of 2 μg/mL and 98.0% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant P. aeruginosa, with an MIC90 of 16 μg/mL and 86.9% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is active against non-Gentamicin-resistant other Pseudomonas spp., with an MIC90 of 8 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.5-2 μg/mL; 18 h) is active against non-Gentamicin-resistant H. influenzae, with an MIC90 of 1 μg/mL[1].
Verdamicin (0.25-4 μg/mL; 18 h) is active against non-Gentamicin-resistant H. parainfluenzae, with an MIC90 of 2 μg/mL[1].
Verdamicin (0.06-32 μg/mL; 18 h) is active against non-Gentamicin-resistant S. aureus, with an MIC90 of 8 μg/mL and 94.8% susceptibility[1].
Verdamicin (≤0.03-32 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant S. epidermidis, with an MIC90 of 32 μg/mL and 75.0% susceptibility[1].
Verdamicin (4->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant E. coli, with an MIC90 of 128 μg/mL and 3.5% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant K. pneumoniae, with an MIC90 of >128 μg/mL and 10.7% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant E. cloacae, with an MIC90 of >128 μg/mL and 5.3% susceptibility[1].
Verdamicin (32->128 μg/mL; 18 h) exhibits no activity against Gentamicin-resistant E. aerogenes, with an MIC90 of >128 μg/mL and 0.0% susceptibility[1].
Verdamicin (16->128 μg/mL; 18 h) exhibits no activity against Gentamicin-resistant C. diversus, with an MIC90 of >128 μg/mL and 0.0% susceptibility[1].
Verdamicin (2->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant P. mirabilis, with an MIC90 of >128 μg/mL and 18.2% susceptibility[1].
Verdamicin (8->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant M. morganii, with an MIC90 of 128 μg/mL and 8.3% susceptibility[1].
Verdamicin (0.5->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant C. freundii, with an MIC90 of >128 μg/mL and 26.3% susceptibility[1].
Verdamicin (1 μg) produces a 17.0 mm zone of inhibition against Staphylococcus aureus ATCC 6538P[3].
Verdamicin (0.08-3.0 μg/mL; 18-24 h) exhibits broad in vitro activity against Staphylococcus aureus (coagulase-positive and coagulase-negative), Streptococcus pyogenes, and Diplococcus pneumoniae with MIC values ranging from 0.08 to 3.0 μg/mL[3].
Verdamicin (0.03-50 μg/mL; 18-24 h) demonstrates potent in vitro activity against susceptible gram-negative bacteria including E. coli, Proteus, Salmonella, Klebsiella, and Serratia (MIC 0.03-0.8 μg/mL), with cross-resistance observed against gentamicin-resistant Pseudomonas strains[3].
Verdamicin (0.125-128 μg/mL; 18 h) is highly active against non-Gentamicin-resistant K. pneumoniae, with an MIC90 of 0.5 μg/mL and 98.8% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant E. cloacae, with an MIC90 of 0.5 μg/mL and 98.2% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant E. aerogenes, with an MIC90 of 1 μg/mL and 98.1% susceptibility[1].
Verdamicin (0.25-0.5 μg/mL; 18 h) is highly active against non-Gentamicin-resistant C. diversus, with an MIC90 of 0.5 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is highly active against non-Gentamicin-resistant P. mirabilis, with an MIC90 of 2 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) is highly active against non-Gentamicin-resistant S. marcescens, with an MIC90 of 0.5 μg/mL and 96.3% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant S. marcescens, with an MIC90 of >128 μg/mL and 10.0% susceptibility[1].
Verdamicin (0.5-4 μg/mL; 18 h) is highly active against non-Gentamicin-resistant M. morganii, with an MIC90 of 2 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25-128 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant C. freundii, with an MIC90 of 64 μg/mL and 72.2% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is active against non-Gentamicin-resistant P. rettgeri, with an MIC90 of 8 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant A. calcoaceticus, with an MIC90 of 2 μg/mL and 98.0% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant P. aeruginosa, with an MIC90 of 16 μg/mL and 86.9% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is active against non-Gentamicin-resistant other Pseudomonas spp., with an MIC90 of 8 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.5-2 μg/mL; 18 h) is active against non-Gentamicin-resistant H. influenzae, with an MIC90 of 1 μg/mL[1].
Verdamicin (0.25-4 μg/mL; 18 h) is active against non-Gentamicin-resistant H. parainfluenzae, with an MIC90 of 2 μg/mL[1].
Verdamicin (0.06-32 μg/mL; 18 h) is active against non-Gentamicin-resistant S. aureus, with an MIC90 of 8 μg/mL and 94.8% susceptibility[1].
Verdamicin (≤0.03-32 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant S. epidermidis, with an MIC90 of 32 μg/mL and 75.0% susceptibility[1].
Verdamicin (4->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant E. coli, with an MIC90 of 128 μg/mL and 3.5% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant K. pneumoniae, with an MIC90 of >128 μg/mL and 10.7% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant E. cloacae, with an MIC90 of >128 μg/mL and 5.3% susceptibility[1].
Verdamicin (32->128 μg/mL; 18 h) exhibits no activity against Gentamicin-resistant E. aerogenes, with an MIC90 of >128 μg/mL and 0.0% susceptibility[1].
Verdamicin (16->128 μg/mL; 18 h) exhibits no activity against Gentamicin-resistant C. diversus, with an MIC90 of >128 μg/mL and 0.0% susceptibility[1].
Verdamicin (2->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant P. mirabilis, with an MIC90 of >128 μg/mL and 18.2% susceptibility[1].
Verdamicin (8->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant M. morganii, with an MIC90 of 128 μg/mL and 8.3% susceptibility[1].
Verdamicin (0.5->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant C. freundii, with an MIC90 of >128 μg/mL and 26.3% susceptibility[1].
Verdamicin (1 μg) produces a 17.0 mm zone of inhibition against Staphylococcus aureus ATCC 6538P[3].
Verdamicin (0.08-3.0 μg/mL; 18-24 h) exhibits broad in vitro activity against Staphylococcus aureus (coagulase-positive and coagulase-negative), Streptococcus pyogenes, and Diplococcus pneumoniae with MIC values ranging from 0.08 to 3.0 μg/mL[3].
Verdamicin (0.03-50 μg/mL; 18-24 h) demonstrates potent in vitro activity against susceptible gram-negative bacteria including E. coli, Proteus, Salmonella, Klebsiella, and Serratia (MIC 0.03-0.8 μg/mL), with cross-resistance observed against gentamicin-resistant Pseudomonas strains[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Bacterial Infection
Verdamicin (0.1-48 mg/kg; subcutaneous injection; single administration; 1 h post-infection) shows broad-spectrum antibacterial efficacy in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CF-1 (male, albino, ~20 g)[3]
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Dosage:0.2-2.5 mg/kg (S. aureus); 2.1-15.3 mg/kg (S. pyogenes); 6.2-20.3 mg/kg (D. pneumoniae); 0.3-21.0 mg/kg (E. coli); 0.1-3.7 mg/kg (K. pneumoniae); 0.4-7.6 mg/kg (Proteus sp.); 1.7-48.0 mg/kg (P. aeruginosa); 0.3-15.0 mg/kg (Salmonella sp.); 0.4-2.9 mg/kg (Serratia sp.)
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Administration:s.c.; single dose; 1 h after infection
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Result:Achieved mean protective doses ranging from 0.2-2.5 mg/kg against S. aureus (6 strains), 2.1-15.3 mg/kg against S. pyogenes (8 strains), 6.2-20.3 mg/kg against D. pneumoniae (3 strains), 0.3-21.0 mg/kg against E. coli (9 strains), 0.1-3.7 mg/kg against K. pneumoniae (7 strains), 0.4-7.6 mg/kg against Proteus sp. (6 strains), 1.7-48.0 mg/kg against P. aeruginosa (10 strains), 0.3-15.0 mg/kg against Salmonella sp. (55 strains), and 0.4-2.9 mg/kg against Serratia sp. (4 strains).
Chemical Information
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CAS No. 49863-48-1
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Masse moléculaire 461.55
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Formule C20H39N5O7
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SMILES
O[C@H]1[C@@H](O[C@@H]2[C@H]([C@@H]([C@H](C[C@H]2N)N)O[C@H]3OC([C@H](C)N)=CC[C@H]3N)O)OC[C@@](C)([C@@H]1NC)O
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Structure Classification
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Initial Source
Pseudomonas spp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Verdamicin Related Classifications
HY-N21935 Related Classifications
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Keywords
- Verdamicin
- 49863-48-1
- Antibiotic
- Bacterial
- Enterobacteriaceae
- Pseudomonas aeruginosa
- Proteus rettgeri
- Micromonospora sagamiensis KY11525
- Micromonospora grisea
- Staphylococcus aureus ATCC 6538P
- Micromonospora inyoensis NRRL3292
- Micromonospora zionensis NRRL5466
- Diplococcus pneumoniae
- Streptococcus pyogenes
- Inhibitor
- inhibitor
- inhibit