Cat. No.: HY-15399

Vigabatrin

(Synonyms: γ-Vinyl-GABA)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.

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Pureté: 99.91%
CAS No.: 68506-86-5
Formule: C₆H₁₁NO₂
Masse moléculaire:129.16

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Vigabatrin Chemical Structure

CAS No.: 68506-86-5

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 68506-86-5
Appearance Solid
Masse moléculaire 129.16
Formule C₆H₁₁NO₂
Color White to off-white
SMILES

C=CC(N)CCC(O)=O
Synonyms

γ-Vinyl-GABA
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (6)

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Redox Biol

Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis. [Abstract]

2021 Oct:46:102082. PMID: 34343908
Cell Rep

GABA regulates IL-1β production in macrophages. [Abstract]

2022 Dec 6;41(10):111770. PMID: 36476877

Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) rescued the effects of GABA on FAD production in M0 macrophages.

Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) rescued the effects of GABA on inflammasome activation in M1 macrophages.

Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) rescued the effects of GABA on mitochondrial functions in M1 macrophages.

Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) rescued the effects of GABA on IL-1β productionin in M1 macrophages.

Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) promoted IL-1β production in macrophages without GABA treatment.
J Exp Bot

GABA negatively regulates adventitious root development in poplar. [Abstract]

2020 Feb 19;71(4):1459-1474. PMID: 31740934
Plants

Effects of GABA and Vigabatrin on the Germination of Chinese Chestnut Recalcitrant Seeds and Its Implications for Seed Dormancy and Storage. [Abstract]

2020 Apr 3;9(4):449. PMID: 32260136
Horticulturae

2023, 9(2), 268.
Animals (Basel)

Effect of GABA-T on Reproductive Function in Female Rats. [Abstract]

2020 Mar 27;10(4):567. PMID: 32230949

Solvant et solubilité

In Vitro:

H₂O : 50 mg/mL (387.12 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

7.7423 mL

38.7117 mL

77.4233 mL

5 mM

1.5485 mL

7.7423 mL

15.4847 mL

10 mM

0.7742 mL

3.8712 mL

7.7423 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (774.23 mM); Suspended solution; Need ultrasonic

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. [Content Brief]

[2]. Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473(1-2):395-7. [Content Brief]

[3]. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	7.7423 mL	38.7117 mL	77.4233 mL	193.5584 mL
	5 mM	1.5485 mL	7.7423 mL	15.4847 mL	38.7117 mL
	10 mM	0.7742 mL	3.8712 mL	7.7423 mL	19.3558 mL
	15 mM	0.5162 mL	2.5808 mL	5.1616 mL	12.9039 mL
	20 mM	0.3871 mL	1.9356 mL	3.8712 mL	9.6779 mL
	25 mM	0.3097 mL	1.5485 mL	3.0969 mL	7.7423 mL
	30 mM	0.2581 mL	1.2904 mL	2.5808 mL	6.4519 mL
	40 mM	0.1936 mL	0.9678 mL	1.9356 mL	4.8390 mL
	50 mM	0.1548 mL	0.7742 mL	1.5485 mL	3.8712 mL
	60 mM	0.1290 mL	0.6452 mL	1.2904 mL	3.2260 mL
	80 mM	0.0968 mL	0.4839 mL	0.9678 mL	2.4195 mL
	100 mM	0.0774 mL	0.3871 mL	0.7742 mL	1.9356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Vigabatrin

6 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Vigabatrin

Activité biologique

Chemical Information

Publications (6)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Vigabatrin Related Classifications

HY-15399 Related Classifications