ZIKV-IN-6
ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC50>50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis.
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- Formule: C27H29NO6
- Masse moléculaire:463.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
IC50 & Target
Zika virus (ZIKV)[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>50 μM
Compound: 22
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37421888] |
| JEG-3 | CC50 |
54.7 μM
Compound: 22
|
Cytotoxicity against human JEG-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human JEG-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37421888] |
| SNB-19 | CC50 |
66.1 μM
Compound: 22
|
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37421888] |
| Vero | CC50 |
65.4 μM
Compound: 22
|
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37421888] |
Chemical Information
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Masse moléculaire 463.52
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Formule C27H29NO6
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SMILES
O=C1C2=C(C(O)=C(N3CCC(C4=CC=CC=C4)CC3)C=C2O)C(C5=C1C[C@@](C)(O)[C@@](C)(O)C5)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)