2. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Monoamine Oxidase Reactive Oxygen Species
  4. CHBO4

CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research.

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CHBO4 Chemical Structure

CHBO4 Chemical Structure

CAS No. : 98991-32-3

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CHBO4 Related Antibodies

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Description

CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research[1].

IC50 & Target[1].

hMAO-B

0.031 μM (IC50)

hMAO-B

0.010 μM (Ki)

In Vitro

CHBO4 (10-500 µg/mL, 48 h) is biologically safe in Vero cells[1].
CHBO4 (128.8 µg/mL, 10 min) can reduce ROS generation in Vero cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHBO4 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Vero cells
Concentration: 10-500 µg/mL
Incubation Time: 48 h
Result: Reduced cell viability percentage with the IC50 value of 128.8 µg/mL
Decreased cellular density, cellular shrinkage, and blebbing exposed to concentrations (100-300 µg/mL) in Vero cells
Molecular Weight

305.14

Formula

C15H10BrFO
CAS No.
SMILES

BrC1=CC=C(C(/C=C/C2=CC=C(F)C=C2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHBO4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHBO498991-32-3CHBO 4CHBO-4Monoamine OxidaseReactive Oxygen SpeciesMAOchalcone-based oximesHMAO-B inhibitionreversibilitycytotoxicityROS assaymolecular dynamicsParkinson'sneurological disorderInhibitorinhibitorinhibit

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