(E)-CHBO4
Based on 1 Customer Validation
(E)-CHBO4 is a MAO-B inhibitor, with an IC50 of 0.023 μM, and can be used for research on the study of Parkinson's disease.
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- Purity : 97.04%
- CAS No.: 126473-61-8
- 화학식: C15H10BrFO
- 분자량:305.14
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
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MAO-B 0.023 μM (IC50) |
Chemical Information
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CAS No. 126473-61-8
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Appearance Solid
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분자량 305.14
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화학식 C15H10BrFO
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Color White to light yellow
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SMILES
FC(C=C1)=CC=C1/C=C/C(C2=CC=C(C=C2)Br)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 50 mg/mL (163.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
순도&문서
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.2772 mL | 16.3859 mL | 32.7718 mL | 81.9296 mL |
| 5 mM | 0.6554 mL | 3.2772 mL | 6.5544 mL | 16.3859 mL | |
| 10 mM | 0.3277 mL | 1.6386 mL | 3.2772 mL | 8.1930 mL | |
| 15 mM | 0.2185 mL | 1.0924 mL | 2.1848 mL | 5.4620 mL | |
| 20 mM | 0.1639 mL | 0.8193 mL | 1.6386 mL | 4.0965 mL | |
| 25 mM | 0.1311 mL | 0.6554 mL | 1.3109 mL | 3.2772 mL | |
| 30 mM | 0.1092 mL | 0.5462 mL | 1.0924 mL | 2.7310 mL | |
| 40 mM | 0.0819 mL | 0.4096 mL | 0.8193 mL | 2.0482 mL | |
| 50 mM | 0.0655 mL | 0.3277 mL | 0.6554 mL | 1.6386 mL | |
| 60 mM | 0.0546 mL | 0.2731 mL | 0.5462 mL | 1.3655 mL | |
| 80 mM | 0.0410 mL | 0.2048 mL | 0.4096 mL | 1.0241 mL | |
| 100 mM | 0.0328 mL | 0.1639 mL | 0.3277 mL | 0.8193 mL |
(E)-CHBO4 Related Classifications
HY-W083026 Related Classifications
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