Clothianidin
Based on 1 publication(s) in Google Scholar
Clothianidin is a neonicotinoid insecticide. Clothianidin shows excellent long-term control effect in small doses against various insect pests such as Coleoptera, Thysanoptera, Lepidoptera, Diptera, Homoptera, Heteroptera, Orthoptera and Isoptera families. Clothianidin has various application methods and high safety for crops.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 210880-92-5
- Formula: C6H8ClN5O2S
- Molecular Weight:249.68
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Human Metabolite Library
HY-L123
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
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Pesticide Compound Library
HY-L183
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
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Mass Spectrometry Human Metabolite Library
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Environmental Pollutant Compound Library
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Publications Citing Use of MedChemExpress (MCE) Clothianidin
More
Biological Activity
Clothianidin (30 nM) exhibits high activity on isolated neurons[2].
Clothianidin (1 µg/L; 36 h) shows sublethal effect on monarch butterfly larvae in milkweed[3].
Clothianidin (0.25 mg/seed and 0.50 mg/seed) has a low concentration in soil and water in farmland cultivated with corn and soybean[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 210880-92-5
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Appearance Solid
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Molecular Weight 249.68
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Formula C6H8ClN5O2S
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Color Off-white to light yellow
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SMILES
CN/C(NCC1=CN=C(Cl)S1)=N\[N+]([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996
Solvent & Solubility
DMSO : 100 mg/mL (400.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[1]. Uneme H. Chemistry of clothianidin and related compounds. J Agric Food Chem. 2011 Apr 13;59(7):2932-7. [Content Brief]
[3]. Pecenka JR, et al. Non-target effects of clothianidin on monarch butterflies. Naturwissenschaften. 2015 Apr;102(3-4):19. [Content Brief]
[4]. de Perre C, et al. Fate and effects of clothianidin in fields using conservation practices. Environ Toxicol Chem. 2015 Feb;34(2):258-65. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0051 mL | 20.0256 mL | 40.0513 mL | 100.1282 mL |
| 5 mM | 0.8010 mL | 4.0051 mL | 8.0103 mL | 20.0256 mL | |
| 10 mM | 0.4005 mL | 2.0026 mL | 4.0051 mL | 10.0128 mL | |
| 15 mM | 0.2670 mL | 1.3350 mL | 2.6701 mL | 6.6752 mL | |
| 20 mM | 0.2003 mL | 1.0013 mL | 2.0026 mL | 5.0064 mL | |
| 25 mM | 0.1602 mL | 0.8010 mL | 1.6021 mL | 4.0051 mL | |
| 30 mM | 0.1335 mL | 0.6675 mL | 1.3350 mL | 3.3376 mL | |
| 40 mM | 0.1001 mL | 0.5006 mL | 1.0013 mL | 2.5032 mL | |
| 50 mM | 0.0801 mL | 0.4005 mL | 0.8010 mL | 2.0026 mL | |
| 60 mM | 0.0668 mL | 0.3338 mL | 0.6675 mL | 1.6688 mL | |
| 80 mM | 0.0501 mL | 0.2503 mL | 0.5006 mL | 1.2516 mL | |
| 100 mM | 0.0401 mL | 0.2003 mL | 0.4005 mL | 1.0013 mL |
Clothianidin Related Classifications
HY-133167 Related Classifications
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