2. Natural Products
  3. Plants Terpenoids
  4. Cucurbitaceae Triterpenes
  5. Citrullus colocynthis (L.) Schrad.
  6. Colocynthin

Colocynthin is a cucurbitane triterpenoid glycoside that can be isolated from the bitter apple (Citrullus colocynthis).

For research use only. We do not sell to patients.

Colocynthin

Colocynthin Chemical Structure

CAS No. : 1398-78-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Colocynthin:

Colocynthin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

Colocynthin is a cucurbitane triterpenoid glycoside that can be isolated from the bitter apple (Citrullus colocynthis)[1].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
> 10 μM
Compound: 10
Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
[PMID: 22044245]
A549 IC50
3.2 μM
Compound: 10
Cytotoxicity against human A549 cells after 96 hrs by MTT assay
Cytotoxicity against human A549 cells after 96 hrs by MTT assay
[PMID: 22044245]
Bel-7402 IC50
> 10 μM
Compound: 10
Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay
[PMID: 22044245]
HCT-8 IC50
> 10 μM
Compound: 10
Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
[PMID: 22044245]
HSC-T6 EC50
3.28 μM
Compound: 2
Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay
Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay
[PMID: 21459003]
HSC-T6 IC50
102 μM
Compound: 2
Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay
Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay
[PMID: 21459003]
HeLa IC50
37 μM
Compound: 2
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
[PMID: 21459003]
HepG2 EC50
45.33 μM
Compound: 2
Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay
Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay
[PMID: 21459003]
HepG2 IC50
226.67 μM
Compound: 2
Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay
[PMID: 21459003]
Molecular Weight

718.83

Formula

C38H54O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]3([H])[C@]([C@@]4([H])C(C(C)(C(C(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=C4)=O)C)=CC3)(C(C[C@@]1([C@@]([C@@H](C2)O)([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)C)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 15 mg/mL (20.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3911 mL 6.9557 mL 13.9115 mL
5 mM 0.2782 mL 1.3911 mL 2.7823 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3911 mL 6.9557 mL 13.9115 mL 34.7787 mL
5 mM 0.2782 mL 1.3911 mL 2.7823 mL 6.9557 mL
10 mM 0.1391 mL 0.6956 mL 1.3911 mL 3.4779 mL
15 mM 0.0927 mL 0.4637 mL 0.9274 mL 2.3186 mL
20 mM 0.0696 mL 0.3478 mL 0.6956 mL 1.7389 mL
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Colocynthin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Colocynthin1398-78-3OthersInhibitorinhibitorinhibit

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