Cyclo(CKLIIF) TFA
Based on 1 Customer Validation
Cyclo(CKLIIF) TFA is an inhibitor of HIF-1α and HIF-2α. The KD values of Cyclo(CKLIIF) TFA for the PAS-B domains of HIF1-α and HIF2-α are 2.6 μM and 2.2 μM, respectively. Cyclo(CKLIIF) TFA disrupts the protein-protein interaction between HIF-1α and HIF-1β. Cyclo(CKLIIF) TFA can be used in cancer research.
For research use only. We do not sell to patients.
- Purity: 98.07%
- Formula: C38H60F3N7O8S
- Molecular Weight:831.99
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Cyclo(CKLIIF) TFA disrupts the protein-protein interaction between HIF-1α and HIF-1β in E. coli RTHS, enabling the bacteria to grow on selective media[1].
Cyclo(CKLIIF) TFA disrupts HIF-1 activity in T-REx-293 cells stably integrated with the HRE-YFP reporter gene[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 831.99
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Formula C38H60F3N7O8S
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Color White to off-white
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Sequence
Cyclo(Cys-Lys-Leu-Ile-Ile-Phe)
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Sequence Shortening
Cyclo(CKLIIF)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (120.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2019 mL | 6.0097 mL | 12.0194 mL | 30.0484 mL |
| 5 mM | 0.2404 mL | 1.2019 mL | 2.4039 mL | 6.0097 mL | |
| 10 mM | 0.1202 mL | 0.6010 mL | 1.2019 mL | 3.0048 mL | |
| 15 mM | 0.0801 mL | 0.4006 mL | 0.8013 mL | 2.0032 mL | |
| 20 mM | 0.0601 mL | 0.3005 mL | 0.6010 mL | 1.5024 mL | |
| 25 mM | 0.0481 mL | 0.2404 mL | 0.4808 mL | 1.2019 mL | |
| 30 mM | 0.0401 mL | 0.2003 mL | 0.4006 mL | 1.0016 mL | |
| 40 mM | 0.0300 mL | 0.1502 mL | 0.3005 mL | 0.7512 mL | |
| 50 mM | 0.0240 mL | 0.1202 mL | 0.2404 mL | 0.6010 mL | |
| 60 mM | 0.0200 mL | 0.1002 mL | 0.2003 mL | 0.5008 mL | |
| 80 mM | 0.0150 mL | 0.0751 mL | 0.1502 mL | 0.3756 mL | |
| 100 mM | 0.0120 mL | 0.0601 mL | 0.1202 mL | 0.3005 mL |
Cyclo(CKLIIF) TFA Related Classifications
HY-P10221A Related Classifications
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