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Cat. No.: HY-190743

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D0209

D0209 is an acetylcholinesterase (AChE) inhibitor (IC₅₀ = 0.53 μM against electric eel; K_i = 0.65 μM). D0209 non-competitively inhibits AChE through interactions with residues of the catalytic site and peripheral anionic site, and has a weak blocking effect on hERG potassium currents. D0209 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₄N₄O₃
Molecular Weight:392.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

D0209 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

electric eel AChE

0.53 μM (IC₅₀)

electric eel AChE

0.65 μM (Ki)

hERG

49.54 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	49.54 μM	Inhibition of hERG tail currents in hERG-expressing HEK293 cells by whole-cell patch-clamp. Inhibition of hERG tail currents in hERG-expressing HEK293 cells by whole-cell patch-clamp.	42912939

In Vitro

D0209 (0.01-20 μM; 30 min preincubation with eeAChE at room temperature; 30 min after ATCI addition) inhibits eeAChE in the Ellman assay with an IC₅₀ of 0.53 μM^[1].
D0209 (0.25-0.75 μM; 30 min preincubation at 37 °C) inhibits eeAChE noncompetitively with a K_i of 0.65 μM^[1].
D0209 (0.1-30 μM) inhibits hERG tail currents in HEK293 cells with an IC₅₀ of 49.54 μM, producing 34.26% inhibition at 30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

Molecular Weight 392.45
Formula C₂₂H₂₄N₄O₃
SMILES

O=C(C1CCN(CC2=CC=CC=C2)CC1)NC(N3)=NC4=C(C=C(OC)C=C4)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Agarwal D, et al. Generative AI-Assisted Molecular Design of AChEIs. Journal of chemical information and modeling. 2026 Oct 12;66(19):12723-12739. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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