1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
  2. ADC Cytotoxin
    DNA Alkylator/Crosslinker
  3. DC10SMe

DC10SMe 

Cat. No.: HY-135122
Handling Instructions

DC10SMe is a DNA alkylator, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC10SMe exhibits IC50s of 15 pM, 12 pM, and 12 pM for Ramos, Namalwa, and HL60/s cancer cells, respectively.

For research use only. We do not sell to patients.

DC10SMe Chemical Structure

DC10SMe Chemical Structure

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Description

DC10SMe is a DNA alkylator, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC10SMe exhibits IC50s of 15 pM, 12 pM, and 12 pM for Ramos, Namalwa, and HL60/s cancer cells, respectively[1].

IC50 & Target[1]

Duocarmycins

 

In Vitro

DC10SMe is a active cyclopropyl form. DC10SMe undergoes N-3 alkylation with an adenine residue and thus form a DNA adduct[1].

Molecular Weight

647.77

Formula

C₃₅H₂₉N₅O₄S₂

SMILES

O=C(C1=CC2=C(C=CC(NC(CCSSC)=O)=C2)N1)NC3=CC4=C(C=C3)NC(C(N5C(C67[[email protected]](C7)C5)=CC(C8=C6C=CC=C8)=O)=O)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DC10SMeADC CytotoxinDNA Alkylator/CrosslinkerDNAalkylatorRamosNamalwaHL60/scancercellInhibitorinhibitorinhibit

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DC10SMe
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