Bradykinin acetate
Based on 19 publication(s) in Google Scholar
Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
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- Reinheit: 99.58%
- CAS. Nr.: 6846-03-3
- Formel: C52H77N15O13.xC2H4O2
- Molecular Weight:1060.21 (free base)
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Bradykinin acetate
More- Autophagy. 2026 Jun 2:1-30. [Abstract]
- Chem Eng J. 2026 Jan 27;530:173437.
- Anal Chem. 2025 Nov 4;97(43):24225-24231. [Abstract]
- Anal Chem. 2024 Aug 17. [Abstract]
- Anal Chem. 2022 Apr 26;94(16):6363-6370. [Abstract]
- Talanta. 2025 Jan 1:282:127045. [Abstract]
- iScience. 2024 May 22;27(6):110075. [Abstract]
- iScience. 2022 Nov 8;25(11):105446. [Abstract]
- ACS Chem Neurosci. 2021 Jul 21;12(14):2619-2628. [Abstract]
- SLAS Discov. 2019 Feb;24(2):158-168. [Abstract]
- J Am Soc Mass Spectrom. 2020 Jul 5. [Abstract]
- World J Surg Oncol. 2019 Feb 27;17(1):44. [Abstract]
- Biochem Biophys Res Commun. 2025 Feb:746:151265. [Abstract]
- Rapid Commun Mass Spectrom. 2023 Feb 15;37(3):e9429. [Abstract]
- Int J Mass Spectrom. 14 October 2021, 116727.
- Int Heart J. 2025 May 31;66(3):485-496. [Abstract]
- bioRxiv. 2026 Mar 30.
- bioRxiv. 2025 Sep 28.
- bioRxiv. 2023 Sep 1.
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Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen
MoreAlle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Bradykinin B2 Receptor (B2R) |
Human Endogenous Metabolite |
Bradykinin acetate is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF[1]. Bradykinin acetate has been reported to be involved in the progression of many types of cancer. Bradykinin acetate treatment promotes the invasion and migration of colorectal cancer cells. Bradykinin acetate treatment stimulates ERK1/2 activation and IL-6 production[2]. Exogenous bradykinin acetate markedly inhibits TF expression in mRNA and protein level induced by LPS in a dose-dependent manner. The NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolish the inhibitory effects of bradykinin acetate on tissue factor expression[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 6846-03-3
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Appearance Solid
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Molecular Weight 1060.21 (free base)
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Formel C52H77N15O13.xC2H4O2
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Color White to off-white
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Sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
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Sequence Shortening
RPPGFSPFR
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (19)
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Journal Impact Factor
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Most Recent
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Autophagy
MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation. [Abstract]2026 Jun 2:1-30. PMID: 42153537 -
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Anal Chem
Two-Dimensional FAIMS-TIMS Separation for Probing Structural Diversity of Peptides with Resolution Exceeding 6500. [Abstract]2025 Nov 4;97(43):24225-24231. PMID: 41116333 -
Anal Chem
Racetrack FAIMS for High-Resolution and High-Sensitivity Characterization of Peptide Conformers. [Abstract]2024 Aug 17. PMID: 39153009 -
Anal Chem
Two-Dimensional FAIMS-IMS Characterization of Peptide Conformers with Resolution Exceeding 1000. [Abstract]2022 Apr 26;94(16):6363-6370. PMID: 35412805 -
Talanta
A robust polymetallic-coated sheathless interface with high acid and alkali resistance for coupling capillary electrophoresis with mass spectrometry. [Abstract]2025 Jan 1:282:127045. PMID: 39418980 -
iScience
Bradykinin induces acute kidney injury after hypothermic circulatory arrest through the repression of the Nrf2-xCT pathway. [Abstract]2024 May 22;27(6):110075. PMID: 38868208
Bradykinin acetate purchased from MedChemExpress. Usage Cited in: iScience. 2024 May 22;27(6):110075. [Abstract]
Representative Western blot images of Nrf2, xCT and GPX4 expression in HK-2 cells treated with 100 μM H2O2 and different concentrations of Bradykinin (0, 10, 50, 100, 500, 1000 nM) for 24 h.
Bradykinin acetate purchased from MedChemExpress. Usage Cited in: iScience. 2024 May 22;27(6):110075. [Abstract]
Flow cytometry of reactive oxygen species (ROS) in HK-2 cells treated with 100 μM H2O2 alone or 100 μM H2O2 plus 100 nM Bradykinin.
Bradykinin acetate purchased from MedChemExpress. Usage Cited in: iScience. 2024 May 22;27(6):110075. [Abstract]
Representative microscopy images of H2DCFDA-stained HK-2 cells treated with 100 μM H2O2 alone or 100 μM H2O2 plus 100 nM Bradykinin to detect ROS.
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iScience
2022 Nov 8;25(11):105446. PMID: 36388955
Bradykinin acetate purchased from MedChemExpress. Usage Cited in: iScience. 2022 Nov 8;25(11):105446. [Abstract]
Fluo-4 direct staining shows the Bradykinin (100 nM)-induced global Ca2+ transients in the KO myoblast versus CTR.
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ACS Chem Neurosci
2021 Jul 21;12(14):2619-2628. PMID: 34184863 -
SLAS Discov
A New Model of Sensorial Neuron-Like Cells for HTS of Novel Analgesics for Neuropathic Pain. [Abstract]2019 Feb;24(2):158-168. PMID: 30383474 -
J Am Soc Mass Spectrom
Wire Desorption Combined with Electrospray Ionization Mass Spectrometry: Direct Analysis of Small Organic and Large Biological Compounds. [Abstract]2020 Jul 5. PMID: 32559077 -
World J Surg Oncol
2019 Feb 27;17(1):44. PMID: 30813916
Bradykinin acetate purchased from MedChemExpress. Usage Cited in: World J Surg Oncol. 2019 Feb 27;17(1):44. [Abstract]
H&E staining showed the flaps from rats treated with Bradykinin (150 μg/kg, i.p.) showed more neovascularization and less necrosis than those from the control group.
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Biochem Biophys Res Commun
Bradykinin attenuates NiSO4-induced autophagy in MIN6 cells and protects islet function in mice by regulating the PI3K/AKT/mTOR signaling pathway. [Abstract]2025 Feb:746:151265. PMID: 39756208 -
Rapid Commun Mass Spectrom
Two-step particle swarm optimization algorithm for effective deconvolution and resolution enhancement of various overlapping peaks. [Abstract]2023 Feb 15;37(3):e9429. PMID: 36346291 -
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Int Heart J
Decrease in Caveolae-Gαq Interaction Mediates Pressure Overload-Induced Cardiac Remodeling in Rats. [Abstract]2025 May 31;66(3):485-496. PMID: 40368774 -
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Handling Instructions (2659 KB)
Verweise
[1]. Hornig B, et al. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors inhumans. Circulation. 1997 Mar 4;95(5):1115-8. [Content Brief]
[2]. Wang G, et al. Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncol Rep. 2014 Oct;32(4):1709-14. [Content Brief]
[3]. Dong R, et al. Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway. Cell Physiol Biochem. 2015;37(4):1592-606. [Content Brief]
[4]. Uchida S, et al. Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats. Auton Neurosci. 2015 Dec;193:57-62. [Content Brief]
[5]. Liu LT, et al. Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. Eur Rev Med Pharmacol Sci. 2015;19(14):2646-50. [Content Brief]
Calculators
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Bradykinin acetate Related Classifications
HY-P0206A Related Classifications
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