Art. -Nr.: HY-172760

CIM-834

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CIM-834 is an orally effective inhibitor of SARS-CoV-2 membrane protein. CIM-834 can prevent the assembly of infectious virus particles without inhibiting the synthesis of viral RNA. CIM-834 can reduce the viral titer in the lungs of SCID mice infected nasally with SARS-CoV-2, block the spread of SARS-CoV-2 among Syrian hamsters, and inhibit the replication of SARS-CoV-2 (including variants) and SARS-CoV. CIM-834 can be used in related research on COVID-19.

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Reinheit: 99.14%
CAS. Nr.: 3104363-32-5
Formel: C₂₇H₄₂N₈O
Molecular Weight:494.68

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CIM-834 Chemical Structure

CAS. Nr.: 3104363-32-5

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Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

CIM-834 (0-10 μM; 3-5 d) potently inhibits SARS-CoV and HCoV-OC43 replication, exhibits partial activity against HCoV-229E, and lacks activity against HCoV-NL63, FIPV, PEDV, and MERS-CoV^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-last	Bioavailability
Mice^[1]	10 mg/kg	i.v.	1013 ng/mL	4714 ng·h/mL	57 %
Mice^[1]	100 mg/kg	p.o.	9889 ng/mL	91977 ng·h/mL	112 %
Golden hamster^[1]	100 (with pre-treatment of 50 mg/kg Ritonavir) mg/kg	p.o.	8640 ng/mL	54614 ng·h/mL	/

In Vivo

CIM-834 (100 mg/kg; p.o.; once or twice daily for 3 consecutive days) reduces the titer of infectious SARS-CoV-2 in the lungs of SCID mice^[1].
CIM-834 (100 mg/kg, p.o., twice daily for 4 days, in combination with ritonavir 50 mg/kg, p.o., twice daily) reduces lung SARS-CoV-2 titers in Syrian hamsters^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CB-17/Icr-Prkdcscid/scid/Rj SCID mice (male, 7-9 weeks old, intranasal infection with SARS-CoV-2 B.1.351)^[1]
Dosage:

100 mg/kg (once daily; twice daily)
Administration:

p.o.; once daily; 3 days; p.o.; twice daily; 3 days
Result:

Significantly and dose-dependently reduced the infectious virus titer and viral RNA load in lung tissue.
Reduced the infectious virus titer in the mouse lungs by more than 3 log₁₀ within 48 hours administration after infection.

Animal Model:

Syrian hamsters (female, 8-10 weeks old, intranasal infection with SARS-CoV-2 USA-WA1/2020)^[1]
Dosage:

100 mg/kg (CIM-834); 50 mg/kg (ritonavir)
Administration:

p.o.; twice daily; 4 days (CIM-834 co-administered with ritonavir)
Result:

Reduced lung viral RNA levels by 3.4 log₁₀ and infectious viral titres by greater than 4 log₁₀.
Resulted in nearly normal lung parenchyma with only very focal perivascular inflammation.
Prevented transmission of SARS-CoV-2 from treated index hamsters to untreated sentinel hamsters.

Chemical Information

CAS. Nr. 3104363-32-5
Appearance Solid
Molecular Weight 494.68
Formel C₂₇H₄₂N₈O
Color White to off-white
SMILES

CC1=NC(N2CCC(N(C)C3=CC(C(NCCN4CCCC4)=O)=CN=N3)CC2)=NC(C)=C1CC(C)C
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (202.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0215 mL

10.1075 mL

20.2151 mL

5 mM

0.4043 mL

2.0215 mL

4.0430 mL

10 mM

0.2022 mL

1.0108 mL

2.0215 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Laporte M, et al. A coronavirus assembly inhibitor that targets the viral membrane protein. Nature. 2025;640(8058):514-523. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0215 mL	10.1075 mL	20.2151 mL	50.5377 mL
	5 mM	0.4043 mL	2.0215 mL	4.0430 mL	10.1075 mL
	10 mM	0.2022 mL	1.0108 mL	2.0215 mL	5.0538 mL
	15 mM	0.1348 mL	0.6738 mL	1.3477 mL	3.3692 mL
	20 mM	0.1011 mL	0.5054 mL	1.0108 mL	2.5269 mL
	25 mM	0.0809 mL	0.4043 mL	0.8086 mL	2.0215 mL
	30 mM	0.0674 mL	0.3369 mL	0.6738 mL	1.6846 mL
	40 mM	0.0505 mL	0.2527 mL	0.5054 mL	1.2634 mL
	50 mM	0.0404 mL	0.2022 mL	0.4043 mL	1.0108 mL
	60 mM	0.0337 mL	0.1685 mL	0.3369 mL	0.8423 mL
	80 mM	0.0253 mL	0.1263 mL	0.2527 mL	0.6317 mL
	100 mM	0.0202 mL	0.1011 mL	0.2022 mL	0.5054 mL

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CIM-834

Anti-Infection Compound Library

Antiviral Compound Library

Orally Active Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CIM-834

Anti-Infection Compound Library

Antiviral Compound Library

Orally Active Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CIM-834 Related Classifications

HY-172760 Related Classifications